The pharyngeal nervous system orchestrates feeding behavior in planarians
The pharyngeal nervous system orchestrates feeding behavior in planarians
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DOI：
10.1126/sciadv.aaz0882
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发表时间：
2020-04-01
期刊：
影响因子：
13.6
通讯作者：
Umesono, Yoshihiko
中科院分区：
文献类型：
--
作者：
Miyamoto, Mai;Hattori, Miki;Umesono, Yoshihiko
Planarians表现出特征的cephalization，但在bilaterians中是独特的，因为他们摄取食物的目标定向运动的躯干定位的咽，以下突出的咽出身体，提出了一个问题，如何Planarians控制这样一个复杂的一套身体运动，以实现强大的喂养。在这里，我们使用淡水涡虫Dugesia japonica显示，一个孤立的咽切除的涡虫体自我导向执行其整个序列的喂养功能：食物的感应，方法，决定摄取，和摄入。通过RNA干扰进行的基因特异性沉默实验表明，咽神经系统（PhNS）不仅需要咽本身的进食功能，而且还需要个体动物的食物定位运动，可能是通过与大脑的通信。这些研究结果揭示了一个意想不到的中心作用的PhNS在独特的形态表型和摄食行为之间的联系，在Planarians。
Planarians exhibit traits of cephalization but are unique among bilaterians in that they ingest food by means of goal-directed movements of a trunk-positioned pharynx, following protrusion of the pharynx out of the body, raising the question of how planarians control such a complex set of body movements for achieving robust feeding. Here, we use the freshwater planarian Dugesia japonica to show that an isolated pharynx amputated from the planarian body self-directedly executes its entire sequence of feeding functions: food sensing, approach, decisions about ingestion, and intake. Gene-specific silencing experiments by RNA interference demonstrated that the pharyngeal nervous system (PhNS) is required not only for feeding functions of the pharynx itself but also for food-localization movements of individual animals, presumably via communication with the brain. These findings reveal an unexpected central role of the PhNS in the linkage between unique morphological phenotypes and feeding behavior in planarians.