The Women's Interagency HIV Study
The Women's Interagency HIV Study
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DOI：
10.1097/00001648-199803000-00004
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发表时间：
1998-03-01
期刊：
影响因子：
5.4
通讯作者：
Feldman, J
中科院分区：
文献类型：
--
作者：
Barkan, SE;Melnick, SL;Feldman, J
妇女机构间艾滋病毒研究包括迄今为止美国最大的人类免疫缺陷病毒(HIV)血清阳性妇女队列(N=2,058)和血清阴性妇女对照队列(N=568)。描述了所采用的方法、培训和质量保证活动。研究人群在1994年10月至1995年11月期间通过美国各地的六个临床联盟(总计23个地点)招募，代表了典型的难以接触到的研究人群。在每个队列中，超过一半的妇女生活在联邦规定的贫困水平以下。这些女性的年龄从16岁到73岁不等；大约四分之一的女性自认为是拉丁裔或西班牙裔，超过一半的非裔美国人不是西班牙裔，不到20%的人是白人，非西班牙裔。自我报告的艾滋病毒暴露风险包括34%的血清阳性妇女和28%的血清阴性妇女使用注射药物，异性接触(42%和26%)，输血风险(4%和3%)，以及未确定的风险(20%对43%)。血清阳性队列的人口统计和艾滋病毒暴露风险特征与美国女性全国报告的艾滋病病例特征相似。艾滋病毒血清阳性和高危血清阴性妇女的这一特征很好的队列代表了未来研究艾滋病毒疾病进展和发病机制的丰富机会。
The Women's Interagency HIV Study comprises the largest U.S. cohort to date of human immunodeficiency virus (HIV)-seropositive women (N = 2,058) with a comparison cohort of seronegative women (N = 568). The methodology, training, and quality assurance activities employed are described. The study population, enrolled between October 1994 and November 1995 through six clinical consortia throughout the United States (totaling 23 sites) represents a typically hard-to-reach study population. More than half of the women in each cohort were living below the federally defined levels of poverty. The women ranged in age from 16 to 73 years; approximately one-quarter self-identified as Latina or Hispanic, over one half as African-American not of Hispanic origin, and less than 20% as white, non-Hispanic origin. Self-reporting of HIV exposure risk included injection drug use by 34% of the seropositive women and 28% of the seronegative women, heterosexual contact (42% ets 26%), transfusion risk (4% us 3%) and no identified risk (20% vs 43%). Demographic and HIV exposure risk characteristics of the seropositive cohort were comparable with characteristics of nationally reported AIDS cases in U.S. women. This well characterized cohort of HIV seropositive and high-risk seronegative women represents a rich opportunity for future studies of HIV disease progression and pathogenesis.