Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23
Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23
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DOI：
10.1006/geno.1998.5425
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发表时间：
1998-09-01
期刊：
影响因子：
4.4
通讯作者：
Knowles, BB
中科院分区：
文献类型：
--
作者：
Ackerman, SL;Knowles, BB
脊椎动物Unc 5基因，像它们的秀丽隐杆线虫对应物一样，定义了一个推定的netrin受体家族。该家族的一个成员Unc 5 h3已被证明在发育中的小鼠小脑的细胞迁移过程中具有重要作用。Unc 5 h3突变的纯合子小鼠是共济失调的，并且具有小脑发育不全和层状结构缺陷。此外，这些小鼠在中脑和脑干中具有异位颗粒和浦肯野细胞。我们已经确定了该基因的人类同源物，UNC 5C，并表明它在成人组织中具有有限的表达模式。通过辐射杂交分析，我们已经确定UNC 5C定位于染色体4 q21-q23标记D4 S1557和D4 S836之间，并与帕金森病基因紧密连锁。(C)北京：科学出版社.
The vertebrate Unc5 genes, like their Caenorhabditis elegans counterpart, define a family of putative netrin receptors. One member of this family, Unc5h3, has been shown to have an important role during cell migration in the developing murine cerebellum. Mice homozygous for mutations in Unc5h3 are ataxic and have cerebellar hypoplasia and laminar structure defects. In addition, these mice have ectopic granule and Purkinje cells in the midbrain and brainstem. We have identified the human homologue of this gene, UNC5C, and shown it to have a restricted expression pattern in adult human tissues. By radiation hybrid analysis, we have determined that UNC5C localizes to chromosome 4q21-q23 between markers D4S1557 and D4S836 and is closely linked to the Parkinson disease gene. (C) 1998 Academic Press.