Deoxy-cytochalasins from a marine-derived fungus Spicaria elegans
Deoxy-cytochalasins from a marine-derived fungus Spicaria elegans
复制标题
DOI：
10.1139/v09-006
复制
发表时间：
2009-03-01
影响因子：
1.1
通讯作者：
Gu, Qian-Qun
中科院分区：
文献类型：
--
作者：
Lin, Zhen-Jian;Zhu, Tian-Jiao;Gu, Qian-Qun
用细胞色素P-450抑制剂处理Spicaria elegans产生了两种新的脱氧细胞松弛素，7-脱氧细胞松弛素Z（7）（1）和7-脱氧细胞松弛素Z（9）（2），它们分别被认为是细胞松弛素Z（7）和Z（9）的可能前体。通过波谱方法确定了化合物的结构，并通过传统的Mosher酯法确定了化合物1的绝对构型。评价了它们对两种癌细胞系的细胞毒性。
Treatment of Spicaria elegans with cytochrome P-450 inhibitor resulted in two new deoxy-cytochalasins, 7-deoxy-cytochalasin Z(7) (1) and 7-deoxy-cytochalasin Z(9) (2), which were recognized as plausible precursors of cytochalasins Z(7) and Z(9), respectively. Their structures were elucidated by spectroscopic methods and the absolute configuration of 1 was determined by the conventional Mosher ester method. Their cytotoxicities against two cancer cell lines were evaluated.