A stochastic model for the normal tissue complication probability (NTCP) and applications
A stochastic model for the normal tissue complication probability (NTCP) and applications
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DOI：
10.1093/imammb/dqw013
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发表时间：
2017-12-01
影响因子：
1.1
通讯作者：
Burger, Martin
中科院分区：
文献类型：
--
作者：
Stocks, Theresa;Hillen, Thomas;Burger, Martin
正常组织并发症概率（NTCP）是对给定放射治疗计划的估计副作用的度量。在这里，我们使用一个随机逻辑出生-死亡过程来定义一个器官特异性和患者特异性的NTCP。我们强调一个渐近的简化，涉及NTCP的解决方案的逻辑微分方程。该框架基于简单的建模假设，并为在临床实践中使用NTCP模型提供了一个框架。例如，我们考虑前列腺癌近距离放射治疗的副作用，如排尿频率增加，尿潴留和急性直肠功能障碍。
The normal tissue complication probability (NTCP) is a measure for the estimated side effects of a given radiation treatment schedule. Here we use a stochastic logistic birth-death process to define an organ-specific and patient-specific NTCP. We emphasize an asymptotic simplification which relates the NTCP to the solution of a logistic differential equation. This framework is based on simple modelling assumptions and it prepares a framework for the use of the NTCP model in clinical practice. As example, we consider side effects of prostate cancer brachytherapy such as increase in urinal frequency, urinal retention and acute rectal dysfunction.