Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis.
Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis.
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类风湿性关节炎 CD8 T 细胞相关生物标志物的鉴定及其泛癌分析
DOI：
10.3389/fimmu.2022.1044909
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发表时间：
2022
影响因子：
7.3
通讯作者：
Zha, Dingsheng
中科院分区：
文献类型：
--
作者：
Zhao, Zhenyu;Ren, Jie;Xie, Siping;Zou, Longchun;Zhao, Qianyue;Zeng, Shan;Zha, Dingsheng
类风湿性关节炎（Rheumatoid arthritis，RA）是一种常见的慢性进行性自身免疫性疾病，严重影响患者的生活质量.然而，在临床实践中仍然缺乏精确的治疗和管理方法。以往的研究表明，CD8+ T细胞在RA的进展中起主导作用。通过多个RA数据集、CIBERSORT和WGCNA算法鉴定与RA中CD8+T细胞密切相关的基因。进行进一步的机器学习分析以鉴定与RA最密切相关的CD8+T细胞相关基因。此外，本研究还探讨了这三个关键基因与33种癌症的关系。在本研究中，10个基因被确定为与RA中的CD8+T细胞密切相关。机器学习分析确定了3个与RA最密切相关的CD8+T细胞相关基因：CD8A，GZMA和PRF1。本研究旨在为RA的临床治疗提供新的思路。
Rheumatoid arthritis (RA), a prevailing chronic progressive autoimmune disease, seriously affects the patient's quality of life. However, there is still a lack of precise treatment and management methods in clinical practice. Previous studies showed that CD8+ T cells take a lead in the progression of RA. Genes closely related to CD8+T cells in RA were identified through multiple RA datasets, CIBERSORT, and WGCNA algorithms. Further machine learning analysis were performed to identify CD8+T cell-related genes most closely related to RA. In addition, the relationship between these three key genes and 33 cancer species was also explored in this study. In this study, 10 genes were identified to be closely related to CD8+T cells in RA. Machine learning analysis identified 3 CD8+T cell-related genes most closely related to RA: CD8A, GZMA, and PRF1. Our research aims to provide new ideas for the clinical treatment of RA.
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影响因子：
7.3
作者：
Higashioka K;Yoshimura M;Sakuragi T;Ayano M;Kimoto Y;Mitoma H;Ono N;Arinobu Y;Kikukawa M;Yamada H;Horiuchi T;Akashi K;Niiro H
通讯作者：
Niiro H
WGCNA：用于加权相关网络分析的 R 包。
影响因子：
3
作者：
Langfelder P;Horvath S
通讯作者：
Horvath S
影响因子：
14.9
作者：
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通讯作者：
Smyth GK
影响因子：
27.4
作者：
Qaiyum, Zoya;Gracey, Eric;Inman, Robert D.
通讯作者：
Inman, Robert D.
影响因子：
13.3
作者：
Santiago, Llipsy;Menaa, Cheikh;Froelich, Christopher J.
通讯作者：
Froelich, Christopher J.