DIABETES IN MICE AFTER COXSACKIE B4 VIRUS-INFECTION
DIABETES IN MICE AFTER COXSACKIE B4 VIRUS-INFECTION
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DOI：
10.1136/bmj.3.5870.25
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发表时间：
1973-01-01
影响因子：
--
通讯作者：
TAYLOR, KW
中科院分区：
文献类型：
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作者：
COLEMAN, TJ;GAMBLE, DR;TAYLOR, KW
用科萨基病毒B4腹腔接种CD 1小鼠，导致病毒给药后12天血糖水平升高至糖尿病值。血清胰岛素仍然不适当的低。胰岛中的光学显微镜变化显示胰岛的单核细胞浸润和β细胞的显著脱粒。腺泡组织似乎变化不大。结论：科萨基B4病毒可引起糖尿病状态，并伴有胰岛细胞损伤。
The intraperitoneal inoculation of CD1mice with Coxsackie virus B4resulted in the raising of blood sugar levels to diabetic values 12 days after the administration of the virus. Serum insulin remained inappropriately low. Light microscopy changes in the islets of Langerhans showed mononuclear cell infiltration of the islets and marked degranulation of the β cells. The acinar tissue appeared to be little changed. It is concluded that Coxsackie B4virus may cause a diabetic state compatible with islet cell damage.