Nickel-catalyzed asymmetric allylation of alkyl Grignard reagents. Effect of ligands, leaving groups and a kinetic resolution with a hard nucleophile
Nickel-catalyzed asymmetric allylation of alkyl Grignard reagents. Effect of ligands, leaving groups and a kinetic resolution with a hard nucleophile
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DOI：
10.1016/s0040-4039(97)00178-0
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发表时间：
1997-03-10
影响因子：
1.8
通讯作者：
RajanBabu, TV
中科院分区：
文献类型：
--
作者：
Nomura, N;RajanBabu, TV
报道了在Ni（0）-膦催化剂存在下，格氏试剂与甲基1，3-二苯基烯丙基醚的不对称加成反应。在MeMgBr加成反应中观察到的动力学拆分（79%ee）对该反应的机理和进一步发展具有重要意义。(C)1997 Elsevier Science Ltd.
Enantioselective addition of Grignard reagents to methyl 1,3-diphenylallyl ether in the presence of Ni(0)-phosphine catalysts is reported Kinetic resolution (79 %ee) observed in the addition of MeMgBr has important implications for the mechanism and further development of this reaction as a valuable synthetic reaction. (C) 1997 Elsevier Science Ltd.