Topical epigallocatechin-3-gallate in the treatment of vitiligo
Topical epigallocatechin-3-gallate in the treatment of vitiligo
复制标题
外用表没食子儿茶素-3-没食子酸酯治疗白癜风
DOI：
10.1111/ajd.13612
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发表时间：
2021-05-28
影响因子：
2
通讯作者：
Xu, AiE
中科院分区：
文献类型：
--
作者：
Hu, Wenting;Zhang, Lingling;Xu, AiE
目的：为初步评价表没食子儿茶素没食子酸酯（Epigallocatechin-5-gallate，EGCG）治疗白癜风的疗效和安全性，进行了为期6个月的临床试验。治疗反应进行了评估的基础上的变化VASI评分减少百分比的体表面积和PGA scores.Results：根据我们的研究结果，这两种药物被发现是显着有效的色素沉着。在EGCG治疗的病变中，病变的VASI从1.19 +/- 10.42降至0.65 +/- 10.58，而在吡美莫司治疗的病变中，病变的VASI从1.18 +/- 10.45降至0.61 +/- 10.56，EGCG治疗组与吡美莫司治疗组VASI评分差异无统计学意义（P = 0.755）。同时，施用EGCG侧的平均PGA评分为4.59 +/- 12.25，而施用吡美莫司侧的平均PGA评分为4.45 +/- 12.02（P = 0.886）。此外，吡美莫司侧和EGCG侧之间的改善程度差异无统计学意义（P = 0.845）。值得注意的是，没有严重的副作用，观察整个study.Conclusion：研究结果表明，局部表没食子儿茶素没食子酸酯可以有效地治疗白癜风。
Objective: To preliminarily assess the efficacy and safety of the topical application of Epigallocatechin-5-gallate (EGCG) in treating vitiligo, a 6-month clinical trial was carried out.Method: Patients were randomly given topical application of EGCG on the assigned lesions, with pimecrolimus being used as the control for twice a day over a 6-month treatment period. Responses to treatment were assessed based on the changes in VASI score for percentage reduction in body surface area and the PGA scores.Results: According to our results, both drugs were discovered to be markedly effective on repigmentation. The VASI of lesion had diminished from 1.19 +/- 10.42 to 0.65 +/- 10.58, in the EGCG-treated lesions, while from 1.18 +/- 10.45 to 0.61 +/- 10.56 in the pimecrolimus-treated lesions, and there was no statistically significant difference in VASI score between the EGCG-treated lesions and pimecrolimus-treated lesions (P = 0.755). Meanwhile, the mean PGA score on the EGCG applied side was 4.59 +/- 12.25, while that was 4.45 +/- 12.02 on the pimecrolimus applied side (P = 0.886) . Furthermore, difference in the improvement degree between pimecrolimus side and EGCG side was not statistically significant (P = 0.845). Notably, no serious side effects were observed throughout the study.Conclusion: Findings of the study indicate that topical EGCG can be effective on treating vitiligo.