Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes.
Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes.
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DOI：
10.1016/s0021-9258(19)36796-1
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发表时间：
1992-10
期刊：
影响因子：
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通讯作者：
Feng Wang;Isabelle Millet;Kim Bottomly;Agnes VignerySII
中科院分区：
文献类型：
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作者：
Feng Wang;Isabelle Millet;Kim Bottomly;Agnes VignerySII
来自文献的证据表明，神经和免疫系统通过影响免疫系统的神经介质和控制神经细胞生长和活性的细胞因子密切相互作用。降钙素基因相关肽（CGRP）是一种神经肽，已被确定在许多组织，包括免疫器官和抑制脾细胞的增殖。我们研究了CGRP是否改变了T淋巴细胞的功能。我们目前的证据表明，CGRP诱导剂量依赖性cAMP的积累，产生白细胞介素2的TH 1细胞，并抑制其生产的白细胞介素2。这些作用被CGRP 8 -37阻止，CGRP 8 -37是一种缺少前7个氨基酸的CGRP拮抗剂。这种CGRP介导的白细胞介素2产生的抑制伴随着白细胞介素2 mRNA积累的减少。CGRP还抑制编码肿瘤坏死因子-α和-β以及干扰素-γ的mRNA的积累。因此，我们已经确定了CGRP抑制脾细胞增殖的一种机制。
Evidence from the literature suggests that the nervous and the immune systems closely interact via neuromediators, which affect the immune system, and cytokines, which control nerve cell growth and activity. Calcitonin gene-related peptide (CGRP) is a neuropeptide that has been identified in numerous tissues including immune organs and inhibits the proliferation of spleen cells. We investigated whether CGRP altered the function of T lymphocytes. We present evidence that CGRP induces a dose-dependent cAMP accumulation in interleukin 2-producing TH1 cells and inhibits their production of interleukin 2. These effects are prevented by CGRP8-37, a CGRP antagonist that is missing the first 7 amino acids. This CGRP-mediated inhibition of interleukin 2 production is accompanied by a decrease in interleukin 2 mRNA accumulation. CGRP also inhibits the accumulation of mRNA coding for tumor necrosis factor-alpha and -beta and interferon-gamma. Thus, we have identified one mechanism by which CGRP inhibits the proliferation of spleen cells.