Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water.
Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water.
复制标题
由于饮用水中摄入的无机砷而导致的肝脏，肺，膀胱和肾脏的癌症潜力。
DOI：
10.1038/bjc.1992.380
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发表时间：
1992-11
影响因子：
8.8
通讯作者：
Kuo, T L
中科院分区：
文献类型：
--
作者：
Chen, C J;Chen, C W;Wu, M M;Kuo, T L
为了比较无机砷诱发各种内脏癌的风险，并评估男性和女性之间的风险差异，癌症的效力指数计算使用的死亡率在台湾西南沿海的慢性砷中毒流行区的居民，和阿米蒂奇-多尔多阶段模型。根据898，806人年和202例肝癌、304例肺癌、202例膀胱癌和64例肾癌死亡资料，观察到饮水砷水平与癌症死亡率之间存在显著的剂量-反应关系。男性摄入10微克/千克/天砷后，患肝癌、肺癌、膀胱癌和肾癌的可能性指数估计分别为4.3 × 10 - 3、1.2 × 10 - 2、1.2 × 10 - 2和4.2 × 10 - 3;在研究区域内，雌性的平均体重分别为3.6 x 10（-3）、1.3 x 10（-2）、1.7 x 10（-2）和4.8 x 10（-3）。无机砷诱导致癌性的多样性且未表现出任何有机性，值得进一步研究。
In order to compare risk of various internal organ cancers induced by ingested inorganic arsenic and to assess the differences in risk between males and females, cancer potency indices were calculated using mortality rates among residents in an endemic area of chronic arsenicism on the southwest coast of Taiwan, and the Armitage-Doll multistage model. Based on a total of 898,806 person-years as well as 202 liver cancer, 304 lung cancer, 202 bladder cancer and 64 kidney cancer deaths, a significant dose-response relationship was observed between arsenic level in drinking water and mortality of the cancers. The potency index of developing cancer of the liver, lung, bladder and kidney due to an intake of 10 micrograms kg day of arsenic was estimated as 4.3 x 10(-3), 1.2 x 10(-2), 1.2 x 10(-2), and 4.2 x 10(-3), respectively, for males; as well as 3.6 x 10(-3), 1.3 x 10(-2), 1.7 x 10(-2), and 4.8 x 10(-3), respectively, for females in the study area. The multiplicity of inorganic arsenic-induced carcinogenicity without showing any organotropism deserves further investigation.