Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis.
Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis.
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DOI：
10.1038/jid.2014.188
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发表时间：
2014-10
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影响因子：
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通讯作者：
Flandiana Yogianti;M. Kunisada;E. Nakano;R. Ono;K. Sakumi;Sugako Oka;Y. Nakabeppu;C. Nishigori
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文献类型：
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作者：
Flandiana Yogianti;M. Kunisada;E. Nakano;R. Ono;K. Sakumi;Sugako Oka;Y. Nakabeppu;C. Nishigori
紫外线照射后产生的活性氧在皮肤肿瘤的发生发展中起着重要作用。我们之前已经报道过，编码8-氧代-7，8-二氢鸟嘌呤(8-oxoG)修复酶的Ogg1基因的缺失会增加反复UVB暴露和调节UVB诱导的炎症反应时小鼠皮肤肿瘤的发生率。螺旋藻因其含有丰富的营养和抗氧化成分而被用作人类食物的补充剂。因此，我们对FS的抑制作用进行了研究。Platensson UVB诱导Ogg1基因敲除(KO)小鼠和野生型(WT)小鼠发生皮肤肿瘤。膳食S。与我们之前没有的数据相比，在这两种类型中，铂类药物抑制了肿瘤的诱导和发展。白垩纪。在Ogg1-KO小鼠和喂食S的白化无毛小鼠的皮肤中，红斑和耳朵肿胀的诱导被抑制，这是UVB诱导的炎症反应的标志之一。与未经处理的小鼠相比，服用钝顶螺旋藻的小鼠在UVB照射后皮肤中8-oxoG的形成显著减少。此外，我们发现了这一点。UVB照射后，p38丝裂原活化蛋白激酶、应激激活蛋白激酶/c-jun氨基末端激酶和细胞外信号调节蛋白激酶的表达均显著下调，尤以Ogg1-KO小鼠为甚。我们的结果表明这就是问题所在。铂通过其抗炎和抗氧化作用，在皮肤中对抗UVB辐射的抗肿瘤作用。
Reactive oxygen species produced in response to UVR are important in skin tumor development. We have previously reported that deficiency of theOgg1gene, encoding the repair enzyme for 8-oxo-7,8-dihydroguanine (8-oxoG), increases skin tumor incidence in mice upon repetitive UVB exposure and modulation of UVB-induced inflammatory response.Spirulina platensisis used as a human food supplement because it contains abundant nutritional and antioxidant components. Therefore, we investigated the inhibitory effects ofS. platensison UVB-induced skin tumor development inOgg1knockout-(KO) mice and the wild-type (WT) counterpart. DietaryS. platensissuppressed tumor induction and development in both genotypes compared with our previous data withoutS. platensis. Induction of erythema and ear swelling, one of the hallmarks of UVB-induced inflammatory responses, was suppressed in the skin ofOgg1-KO mice and albino hairless mice fed with dietaryS. platensis.Compared with untreated mice,S. platensis-administered mice showed significantly reduced 8-oxoG formation in the skin after UVB exposure. Moreover, we found thatS. platensiseffectively downregulated the signal proteins p38 mitogen-activated protein kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and extracellular signal–regulated kinase after UVB exposure especially inOgg1-KO mice. Our results suggest thatS. platensisexerts antitumor effects against UVB irradiation in the skin through its anti-inflammatory and antioxidant effects.