Characterization of a Temporary Peripheral Nerve Stimulation Electrode Utilizing a Bioabsorbable Suture Substrate.
Characterization of a Temporary Peripheral Nerve Stimulation Electrode Utilizing a Bioabsorbable Suture Substrate.
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使用生物可吸收缝合基板的临时性周围神经刺激电极的特征。
DOI：
10.1109/embc48229.2022.9871604
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发表时间：
2022-07
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周围神经损伤（PNI）后的电刺激有可能促进受损纤维束更快速和完全的恢复。虽然永久性植入器械通常用于治疗慢性或持续性疾病，但由于成本高、手术损伤、刺激、感染和植入部位持续性炎症的风险增加，它们不是瞬时医学治疗的理想解决方案。此外，移除放置在外周神经上或周围的临时引线可能具有神经损伤的不可接受的风险，这在开发用于PNI治疗的疗法中是适得其反的。提供有效临床刺激同时能够无害生物吸收的瞬时装置可以克服这些领域的关键挑战。然而，目前的生物可吸收装置在其稳健性方面受到限制，并且需要复杂的制造策略和新型材料，这可能使其临床转化途径复杂化。在这项研究中，我们提出了一个简单的生物可吸收/可生物降解的电极，通过修改标准的可吸收缝线，我们提出的数据表征我们的原型的稳定性在体外和体内。
Electrical stimulation after peripheral nerve injury (PNI) has the potential to promote more rapid and complete recovery of damaged fiber tracts. While permanently implanted devices are commonly used to treat chronic or persistent conditions, they are not ideal solutions for transient medical therapies due to high costs, increased risk of surgical injury, irritation, infection, and persistent inflammation at the site of the implant. Furthermore, removal of temporary leads placed on or around peripheral nerves may have unacceptable risk for nerve injury, which is counterproductive in developing therapies for PNI treatment. Transient devices which provide effective clinical stimulation while being capable of harmless bioabsorption may overcome key challenges in these areas. However, current bioabsorbable devices are limited in their robustness and require complex fabrication strategies and novel materials which may complicate their clinical translation pathway. In this study, we present a simple bioabsorbable / biodegradable electrode fabricated by modifying standard absorbable sutures, and we present data characterizing our prototype’s stability in vitro and in vivo.