Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study.
Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study.
复制标题
青少年肌阵挛性癫痫局部自发脑活动的改变：一项初步静息态功能磁共振成像研究
DOI：
10.1155/2016/3547203
复制
发表时间：
2016
影响因子：
3.1
通讯作者：
Yao D
中科院分区：
文献类型：
--
作者：
Jiang S;Luo C;Liu Z;Hou C;Wang P;Dong L;Zhong C;Lai Y;Xia Y;Yao D
目的。本研究的目的是评估青少年肌阵挛癫痫（JME）患者大脑的区域同步性。方法。静息态 fMRI 数据来自 21 名 JME 患者和 22 名健康受试者。使用区域同质性（ReHo）来分析全脑的自发活动。进行双样本 t 检验来检测两组之间的 ReHo 差异。进一步计算 ReHo 值和癫痫发作特征之间的相关性。主要发现。与健康对照相比，患者双侧丘脑和运动相关皮层区域的 ReHo 显着增加，小脑和枕顶叶的 ReHo 显着减少。此外，左旁中央小叶的 ReHo 值较大与患者发病年龄较大有关。意义。这些发现暗示 JME 中丘脑运动皮层网络的异常与癫痫样活动的发生和传播有关。此外，我们的研究支持局部大脑自发活动是研究癫痫活动的潜在工具，并为理解 JME 的病理生理机制提供了重要的见解。
Purpose. The purpose of this study was to evaluate the regional synchronization of brain in patients with juvenile myoclonic epilepsy (JME). Methods. Resting-state fMRI data were acquired from twenty-one patients with JME and twenty-two healthy subjects. Regional homogeneity (ReHo) was used to analyze the spontaneous activity in whole brain. Two-sample t-test was performed to detect the ReHo difference between two groups. Correlations between the ReHo values and features of seizures were calculated further. Key Findings. Compared with healthy controls, patients showed significantly increased ReHo in bilateral thalami and motor-related cortex regions and a substantial reduction of ReHo in cerebellum and occipitoparietal lobe. In addition, greater ReHo value in the left paracentral lobule was linked to the older age of onset in patients. Significance. These findings implicated the abnormality of thalamomotor cortical network in JME which were associated with the genesis and propagation of epileptiform activity. Moreover, our study supported that the local brain spontaneous activity is a potential tool to investigate the epileptic activity and provided important insights into understanding the pathophysiological mechanisms of JME.