Executive and Visuospatial Dysfunction in Patients With Primary Restless Legs Syndrome/Willis-Ekbom Disease: Study of a Chinese Population
Executive and Visuospatial Dysfunction in Patients With Primary Restless Legs Syndrome/Willis-Ekbom Disease: Study of a Chinese Population
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原发性不安腿综合征/Willis-Ekbom 病患者的执行和视觉空间功能障碍：中国人群研究
DOI：
10.5664/jcsm.7106
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发表时间：
2018-01-01
影响因子：
4.3
通讯作者：
Ma, Jianfang
中科院分区：
文献类型：
--
作者：
Li, Gen;Tang, Huidong;Ma, Jianfang
研究目的：探讨中国人群中原发性不宁腿综合征/Willis-Ekbom病(RLS/WWE)患者的认知功能。方法：对40例药物未用药的RLS/WEW患者和40例年龄、性别、文化程度相匹配的对照患者进行认知功能评定，包括中文版简易智力状态检查(MMSE-C)、画钟测验(CDT)、听觉言语学习测验(AVLT)、雷奥氏复杂图形测验(CFT)、结果：RLS/WEB患者在颜色词测试中表现较差(Stroop卡片C时间：102.36±17.12vs87.08+/-7.73秒，P=0.033；干扰指数：3.39+/-0.38对2.90+/-0.15，P<；在调整汉密尔顿焦虑量表评分、汉密尔顿抑郁量表评分、爱普沃斯嗜睡量表评分和匹兹堡睡眠质量指数总分排除伴随睡眠障碍、焦虑和抑郁的混杂因素后，CDT(16分法：10.13+/-3.94对13.98+/-1.79，P=.0002)、CFT(24.05+/-9.28比33.74+/-1.59，P=.008)和CDT比对照组(16分法：10.13+/-3.94比13.98+/-1.79，P=.0002)。结论：我们的研究提示中国原发RLS/WEB患者的执行和视觉空间领域的认知功能可能受到干扰。
Study Objectives: The aim of the study was to investigate the cognitive function of patients with primary restless legs syndrome/Willis-Ekbom disease (RLS/WED) in a Chinese population.Methods: A total of 40 patients with RLS/WED who were drug naive and 40 controls, matched by age, sex, and educational level, were evaluated by cognitive function assessments, including the Chinese version of the Mini-Mental State Examination (MMSE-C), clock drawing test (CDT), Auditory Verbal Learning Test (AVLT), Rey-Osterrieth Complex Figure Test (CFT), and Stroop Color Word Test (SCWT).Results: Patients with RLS/WED showed worse performance on the SCWT (Stroop Card C time: 102.36 +/- 17.12 versus 87.08 +/- 7.73 seconds, P= .033; Interference Index: 3.39 +/- 0.38 versus 2.90 +/- 0.15, P < .0001), CFT (24.05 +/- 9.28 versus 33.74 +/- 1.59, P = .008), and CDT than controls (16-score method: 10.13 +/- 3.94 versus 13.98 +/- 1.79, P = .0002) after adjusting for Hamilton Anxiety Scale score, Hamilton Depression Scale score, Epworth Sleepiness Scale score, and Pittsburgh Sleep Quality Index total score to eliminate the confounders of concomitant sleep disturbances, anxiety, and depression. Conclusions: Our study suggested that cognitive functions involving executive and visuospatial domains might be disturbed in Chinese patients with primary RLS/WED.