Differential loss of ancestral gene families as a source of genomic divergence in animals
Differential loss of ancestral gene families as a source of genomic divergence in animals
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DOI：
10.1098/rsbl.2003.0124
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发表时间：
2004-02-07
影响因子：
4.7
通讯作者：
Friedman, R
中科院分区：
文献类型：
--
作者：
Hughes, AL;Friedman, R
系统发育的方法被用来重建模式的一个明显的损失2106祖先基因家族的四种动物基因组（秀丽隐杆线虫，果蝇，人类和河豚）。在无脊椎动物中发现祖先基因家族的丢失率比脊椎动物高得多。这些结果表明，祖先基因家族的差异丢失可能是生物进化多样化的一个重要因素。
A phylogenetic approach was used to reconstruct the pattern of an apparent loss of 2106 ancestral gene families in four animal genomes (Caenorhabditis elegans, Drosophila melanogaster, human and fugu). Substantially higher rates of loss of ancestral gene families were found in the invertebrates than in the vertebrates. These results indicate that the differential loss of ancestral gene families can be a significant factor in the evolutionary diversification of organisms.