Photodynamic therapy of port wine stains-a report of 238 cases
Photodynamic therapy of port wine stains-a report of 238 cases
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DOI：
10.1016/j.pdpdt.2007.01.001
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发表时间：
2007-03-01
影响因子：
3.3
通讯作者：
Liu, Xue-Jian
中科院分区：
文献类型：
--
作者：
Qin, Zhong-Ping;Li, Ke-Lei;Liu, Xue-Jian
目的：回顾性分析血管作用光动力疗法（PDT）治疗鲜红斑痣（PWS）的临床效果。方法：1997年9月至2003年6月，对238例2～56岁的PWS患者采用铜蒸气激光进行光癌素介导的PDT治疗。其中，粉红色病灶（I型）20例，红色病灶（II型）44例，暗红色病灶（III型）99例，紫色病灶（IV型）51例，结节或增厚病灶（V型）24例。患者接受缓慢静脉注射光癌素（4-5 mg/kg b.w.），并在药物注射期间以 160-260J/cm(2) 的剂量水平、70-100 mW/cm(2) 的注量率提供光。对一些患者重复相同的程序2-4次。所有患者均随访6个月至4年。结果：显效68例（28.6%），良效76例（31.9%），一般87例（36.6%），差或无反应7例（2.9%）。三例报告了继发性疤痕形成。 5-20 岁患者的良好反应率最高。据报道，部分患者出现PDT引起的过渡性色素沉着，但在3-6个月内无需治疗即可消失。结论：铜蒸气激光PDT可以选择性破坏PWS血管，而不损伤正常皮肤。如果技术应用得当，可以治愈浅表病变，也可以大大改善厚层病变。 (C) 2007 Elsevier B.V. 保留所有权利。
Objective: Retrospective analysis of clinical effects of vascular acting photodynamic therapy (PDT) for the treatment of port wine stains (PWS).Methods: Between September 1997 and June 2003, a total of 238 PWS cases (2-56 years old) were treated with Photocarcinorin-mediated PDT using a copper vapour laser. Among them, 20 cases were pink lesions (Type I), 44 cases red lesions (Type II), 99 cases dark red lesions (Type III), 51 cases purple lesions (Type IV), and 24 cases nodular or thickened lesions (Type V), respectively. Patient received a slow intravenous injection of Photocarcinorin (4-5 mg/kg b.w.) and light was delivered during the drug injection at dose levels of 160-260J/cm(2) at fluence rates of 70-100 mW/cm(2). The same procedure was repeated 2-4 times for some patients. All patients were followed up for 6 months to 4 years.Results: Sixty-eight cases (28.6%) showed excellent response, 76 cases (31.9%) good response, 87 cases (36.6%) fair response and 7 cases (2.9%) poor or no response. Secondary scar formation was reported in three cases. Highest good to excellent response rates were seen in patients of 5-20 years old. PDT-induced transitional hyperpigmentation was reported in some patients but disappeared without the need of treatment within 3-6 months.Conclusion: Copper vapour laser PDT can selectively destroy PWS vessels without damage to the normal skin. If the technique is applied properly, it can cure superficial lesions and greatly improve thick lesions. (C) 2007 Elsevier B.V. All rights reserved.