Clinical characteristics and functional outcomes of West Nile fever
Clinical characteristics and functional outcomes of West Nile fever
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DOI：
10.7326/0003-4819-141-5-200409070-00010
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发表时间：
2004-09-07
影响因子：
39.2
通讯作者：
Gerber, SI
中科院分区：
文献类型：
--
作者：
Watson, JT;Pertel, PE;Gerber, SI
背景资料：西尼罗河热，被认为是西尼罗河病毒感染的一种非严重表现，在美国尚未得到很好的临床描述。在2002年，伊利诺斯州有884例西尼罗河病毒感染的记录病例，66例相关死亡。目的：描述西尼罗河热的症状和功能结果。设计：病例系列。设置：伊利诺斯州。患者：98名社区居民患者，实验室证据显示西尼罗河病毒感染，但无脑膜炎、脑炎或急性弛缓性麻痹的临床证据。干预：门诊访谈：测量：患者报告的感染症状的存在和持续时间，与感染相关的缺勤，卫生保健的使用，以及对日常活动的影响。结果如下：在98名患者中，96%的患者出现疲劳，中位时间为36天，81%的患者出现发热，中位时间为5天，71%的患者出现头痛，中位时间为10天，61%的患者出现肌无力，中位时间为28天，53%的患者难以集中注意力，中位时间为14天。30名受访者报告住院治疗，中位住院时间为5天。在发病后30天，63%的受访者继续有症状。持续时间并没有随着年龄的增加而显着变化。在72例正常参加工作或上学的患者中，57（79%）不能参加，因为疾病（中位缺席，10天）。限制：召回偏见可能已被引入疾病发作和面试之间的延迟和自我报告的疾病information.Conclusions：西尼罗河热是一个更严重的疾病比以前记录。除了西尼罗河脑膜脑炎病例外，强制报告西尼罗河热病例可以更准确和及时地识别西尼罗河病毒感染的地理分布，并可以为公共卫生干预措施提供信息。
Background: West Nile fever, considered a nonsevere manifestation of West Nile virus infection, has not been clinically well described in the United States. In 2002, Illinois had 884 documented cases of West Nile virus infection with 66 associated deaths.Objective: To describe the symptoms and functional outcomes of West Nile fever.Design: Case series.Setting: Illinois.Patients: 98 community-dwelling patients with laboratory evidence of West Nile virus infection but no history of clinical evidence of meningitis, encephalitis, or acute flaccid paralysis.Intervention: Outpatient interviews.Measurements: Presence and duration of patient-reported symptoms of infection, symptom-associated absenteeism, health care use, and impact on daily activities. Results: Of 98 patients, 96% had fatigue for a median of 36 days, 81% had fever for a median of 5 days, 71% had headache for a median of 10 days, 61% had muscle weakness for a median of 28 days, and 53% had difficulty concentrating for a median of 14 days. Thirty respondents reported hospitalization, with a median stay of 5 days. At 30 days after onset, 63% of respondents continued to have symptoms. Duration did not vary significantly with increased age. Among the 72 patients who normally attended work or school, 57 (79%) could not attend because of illness (median absence, 10 days).Limitations: Recall bias could have been introduced by the delay between illness onset and interview and by self-reporting of illness information.Conclusions: West Nile fever is a more severe illness than has previously been documented. Mandatory reporting of West Nile fever cases in addition to West Nile meningoencephalitis cases could allow more accurate and timely recognition of the geographic distribution of West Nile virus infections and could inform public health interventions.