INTERMODULATION DISTORTION (F2-F1) IN INNER HAIR CELL AND BASILAR-MEMBRANE RESPONSES
INTERMODULATION DISTORTION (F2-F1) IN INNER HAIR CELL AND BASILAR-MEMBRANE RESPONSES
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DOI：
10.1121/1.406692
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发表时间：
1993-04-01
影响因子：
2.4
通讯作者：
DOLAN, DF
中科院分区：
文献类型：
--
作者：
NUTTALL, AL;DOLAN, DF
豚鼠圆窗（RW）记录显示，对于高频（> 8 kHz）音对，在F2-F1处的二次差音（QDT）频率处有较大的响应。RW响应的幅度取决于频率和原色的电平。所产生的QDT耳蜗麦克风是最大的原色，频率分离约为900 Hz。其来源可能是耳蜗基底部位的毛细胞的局部活动，高频音调在此处相互作用。从Corti器官内的位置的QDT测量表明，QDT的幅度是最大的内毛细胞（IHC）区域和单调增加的差异，在初级的频率降低。作为IHC细胞内ac受体电位测量，QDT似乎是对细胞的机械刺激的结果，而不是作为IHC中非线性转导的固有特性。但在基底膜的速度响应中，同样形式的QDT并不明显。这些结果表明，外毛细胞（OHC）产生强大的二次畸变产物机械力来刺激内毛细胞。在基底膜运动中，这种机械驱动可能不存在，或者是一个弱的组成部分。
Round window (RW) recordings in guinea pigs show a large response at the frequency of the quadratic difference tone (QDT) at F2-F1 for high-frequency ( > 8 kHz) tone pairs. The magnitude of the RW response is dependent on frequency and level of the primaries. The QDT cochlear microphonic produced is largest for primaries with a frequency separation of approximately 900 Hz. Its source is probably the local activity of hair cells in basal cochlear locations where the high-frequency tones interact. QDT measurements from locations inside the organ of Corti show that the magnitude of the QDT is largest in the inner hair cell (IHC) region and monotonically increases as the difference in the frequency of the primaries decreases. Measured as IHC intracellular ac receptor potential, the QDT appears to be the result of a mechanical stimulus to the cell rather than as an inherent property of the nonlinear transduction in the IHC. However, QDT of the same form is not evident in the velocity responses of the basilar membrane. These results suggest that the outer hair cells (OHC) produce a strong quadratic distortion product mechanical force to stimulate inner hair cells. This mechanical drive may not be present, or is a weak component, in basilar membrane motion.