EXERCISE TRAINING AND NUTRITIONAL SUPPLEMENTATION FOR PHYSICAL FRAILTY LN VERY ELDERLY PEOPLE
EXERCISE TRAINING AND NUTRITIONAL SUPPLEMENTATION FOR PHYSICAL FRAILTY LN VERY ELDERLY PEOPLE
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DOI：
10.1056/nejm199406233302501
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发表时间：
1994-06-23
影响因子：
158.5
通讯作者：
EVANS, WJ
中科院分区：
文献类型：
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作者：
FIATARONE, MA;ONEILL, EF;EVANS, WJ
背景资料。虽然骨骼肌停用和营养不良经常被认为是导致老年人虚弱的潜在可逆原因，但针对这些缺陷的干预措施的有效性尚未被仔细研究。我们进行了一项随机、安慰剂对照试验，对100名体弱的养老院居民在10周的时间里，比较了递增阻力运动训练、多种营养素补充、两种干预措施以及两者都不干预的情况。参加研究的63名女性和37名男性的平均(+/-SE)年龄为87.1+/-0.6岁(范围从72岁到98岁)；94%的受试者完成了这项研究。接受运动训练的受试者肌肉力量增加了113+/-8%，而非运动受试者的肌力增加了3+/-9%(P
Background. Although disuse of skeletal muscle and undernutrition are often cited as potentially reversible causes of frailty in elderly people, the efficacy of interventions targeted specifically at these deficits has not been carefully studied.Methods. We conducted a randomized, placebo-controlled trial comparing progressive resistance exercise training, multinutrient supplementation, both interventions, and neither in 100 frail nursing home residents over a 10-week period.Results. The mean (+/-SE) age of the 63 women and 37 men enrolled in the study was 87.1+/-0.6 years (range, 72 to 98); 94 percent of the subjects completed the study. Muscle strength increased by 113+/-8 percent in the subjects who underwent exercise training, as compared with 3+/-9 percent in the nonexercising subjects (P