The evolution and international spread of extensively drug resistant Shigella sonnei.
The evolution and international spread of extensively drug resistant Shigella sonnei.
复制标题
广泛耐药宋内志贺氏菌的进化和国际传播。
DOI：
10.1038/s41467-023-37672-w
复制
发表时间：
2023-04-08
影响因子：
16.6
通讯作者：
Baker, Kate S.
中科院分区：
文献类型：
--
作者：
Mason, Lewis C. E.;Greig, David R.;Cowley, Lauren A.;Partridge, Sally R.;Martinez, Elena;Blackwell, Grace A.;Chong, Charlotte E.;De Silva, P. Malaka;Bengtsson, Rebecca J.;Draper, Jenny L.;Ginn, Andrew N.;Sandaradura, Indy;Sim, Eby M.;Iredell, Jonathan R.;Sintchenko, Vitali;Ingle, Danielle J.;Howden, Benjamin P.;Lefevre, Sophie;Njamkepo, Elisabeth;Weill, Francois-Xavier;Ceyssens, Pieter-Jan;Jenkins, Claire;Baker, Kate S.
宋内氏志贺氏菌引起志贺氏菌病，这是一种严重的胃肠道疾病，在男男性行为者(MSM)中可通过性传播。宋内氏葡萄球菌的多重耐药性很常见，包括对世界卫生组织推荐的治疗方案阿奇霉素和环丙沙星的耐药性。最近，英国报告了一起与男男性接触者相关的产超广谱β-内酰胺酶、广泛耐药的宋内氏葡萄球菌的暴发。在这里，我们的目标是确定暴发毒株的遗传基础、进化历史和国际传播。我们对来自英国、澳大利亚、比利时、法国和美利坚合众国的3,304株分离物进行的基因组流行病学分析显示，2018年发生了一次与国际有关的疫情，最近的一位共同祖先携带一种低适应成本抗性质粒，此前在旅行相关亚系中观察到了这种质粒。我们的结果突出了水平传播的抗菌素耐药性的持续威胁，以及继续努力实现基因组监测数据的早期和开放的国际共享的价值。在英国，男男性行为者中志贺氏菌病病例的增加与一种广泛耐药的宋内氏志贺氏菌株有关。在这项基因组流行病学研究中，作者调查了暴发毒株的遗传基础、进化史和国际传播。
Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common including against World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum β-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom. Here, we aimed to identify the genetic basis, evolutionary history, and international dissemination of the outbreak strain. Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a most recent common ancestor in 2018 carrying a low-fitness cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri. Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data. An increase in shigellosis cases among men who have sex with men in the United Kingdom has been linked to an extensively drug-resistant strain of Shigella sonnei. In this genomic epidemiology study, the authors investigate the genetic basis, evolutionary history, and international dissemination of the outbreak strain.
登录
查看更多内容
影响因子：
16.6
作者：
Bradley P;Gordon NC;Walker TM;Dunn L;Heys S;Huang B;Earle S;Pankhurst LJ;Anson L;de Cesare M;Piazza P;Votintseva AA;Golubchik T;Wilson DJ;Wyllie DH;Diel R;Niemann S;Feuerriegel S;Kohl TA;Ismail N;Omar SV;Smith EG;Buck D;McVean G;Walker AS;Peto TE;Crook DW;Iqbal Z
通讯作者：
Iqbal Z
影响因子：
6.4
作者：
Bengtsson RJ;Dallman TJ;Allen H;De Silva PM;Stenhouse G;Pulford CV;Bennett RJ;Jenkins C;Baker KS
通讯作者：
Baker KS
影响因子：
4.2
作者：
Collins, Jennifer P.;Friedman, Cindy R.;Watkins, Louise Francois
通讯作者：
Watkins, Louise Francois
影响因子：
9.4
作者：
Bardsley, Megan;Jenkins, Claire;Dallman, Timothy J.
通讯作者：
Dallman, Timothy J.
影响因子：
14.2
作者：
Allen, H.;Mitchell, H. D.;Jenkins, C.
通讯作者：
Jenkins, C.