Idiopathic intracranial hypertension - The prevalence and morphology of sinovenous stenosis
Idiopathic intracranial hypertension - The prevalence and morphology of sinovenous stenosis
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DOI：
10.1212/01.wnl.0000066683.34093.e2
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发表时间：
2003-05-13
期刊：
影响因子：
9.9
通讯作者：
terBrugge, KG
中科院分区：
文献类型：
--
作者：
Farb, RI;Vanek, I;terBrugge, KG
目的：使用自动触发椭圆中心有序三维钆增强MR静脉成像（ATECO MRV）确定特发性颅内高压（IIH）患者窦静脉阻塞的患病率和性质。方法：在一项前瞻性对照研究中，29例确诊IIH患者和59例对照患者接受了ATECO MRV。以随机设盲的方式，由三名阅片人评价图像。使用一种新的评分系统，每位阅片者对每位患者的横窦和乙状窦狭窄程度进行评分。结果：三位阅片人对分级系统的应用非常一致。在29例IIH患者中有27例出现双侧窦静脉狭窄，而在59例对照患者中仅有4例。结论：使用ATECO MRV和一种新的定量窦静脉狭窄分级系统，作者可以识别IIH患者，灵敏度和特异性为93%。
Objective: To determine the prevalence and nature of sinovenous obstruction in idiopathic intracranial hypertension (IIH) using auto-triggered elliptic-centric-ordered three-dimensional gadolinium-enhanced MR venography (ATECO MRV). Methods: In a prospective controlled study, 29 patients with established IIH as well as 59 control patients underwent ATECO MRV. In a randomized blinded fashion, three readers evaluated the images. Using a novel scoring system, each reader graded the degree of stenosis seen in the transverse and sigmoid sinuses of each patient. Results: There was excellent agreement across the three readers for application of the grading system. Substantial bilateral sinovenous stenoses were seen in 27 of 29 patients with IIH and in only 4 of 59 control patients. Conclusion: Using ATECO MRV and a novel grading system for quantifying sinovenous stenoses, the authors can identify IIH patients with sensitivity and specificity of 93%.