fMRI and Sleep Correlates of the Age-Related Impairment in Motor Memory Consolidation
fMRI and Sleep Correlates of the Age-Related Impairment in Motor Memory Consolidation
复制标题
DOI：
10.1002/hbm.22426
复制
发表时间：
2014-08-01
影响因子：
4.8
通讯作者：
Doyon, Julien
中科院分区：
文献类型：
--
作者：
Fogel, Stuart M.;Albouy, Genevieve;Doyon, Julien
行为研究表明，老年人表现出正常的运动序列学习（MSL），但矛盾的是，显示受损的巩固新的记忆痕迹。然而，这种损害的神经和生理机制是完全未知的。在这里，我们试图确定，通过功能磁共振成像MSL和脑电图（EEG）记录在白天睡眠期间，这种年龄相关的运动记忆缺陷的功能相关性和生理特征。正如预测的那样，老年受试者在表现上没有表现出睡眠依赖性的增益（即，反映巩固的行为变化），并与年轻受试者相比减少了睡眠纺锤波。大脑成像分析还显示，在整个保留时间间隔内，壳核和相关大脑区域的活动变化与睡眠纺锤波有关。这种纹状体活动的变化在年轻受试者中增加，但在老年受试者中减少。这些研究结果表明，老年人睡眠依赖性运动记忆巩固的缺陷与睡眠纺锤波振荡的减少和皮质-纹状体网络活动的相关减少有关。(C)2013 Wiley Periodicals，Inc.
Behavioral studies indicate that older adults exhibit normal motor sequence learning (MSL), but paradoxically, show impaired consolidation of the new memory trace. However, the neural and physiological mechanisms underlying this impairment are entirely unknown. Here, we sought to identify, through functional magnetic resonance imaging during MSL and electroencephalographic (EEG) recordings during daytime sleep, the functional correlates and physiological characteristics of this age-related motor memory deficit. As predicted, older subjects did not exhibit sleep-dependent gains in performance (i.e., behavioral changes that reflect consolidation) and had reduced sleep spindles compared with young subjects. Brain imaging analyses also revealed that changes in activity across the retention interval in the putamen and related brain regions were associated with sleep spindles. This change in striatal activity was increased in young subjects, but reduced by comparison in older subjects. These findings suggest that the deficit in sleep-dependent motor memory consolidation in elderly individuals is related to a reduction in sleep spindle oscillations and to an associated decrease of activity in the cortico-striatal network. (C) 2013 Wiley Periodicals, Inc.