The ADF/cofilin family: accelerators of actin reorganization.
The ADF/cofilin family: accelerators of actin reorganization.
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DOI：
10.1007/978-3-540-46560-7_10
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发表时间：
2001
影响因子：
--
通讯作者：
A. McGough;B. Pope;A. Weeds
中科院分区：
文献类型：
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作者：
A. McGough;B. Pope;A. Weeds
肌动蛋白聚合和细胞骨架重组在细胞运动和许多形式的运动中起重要作用，包括吞噬作用和胞质分裂。肌动蛋白丝在体外的组装速率实际上是扩散控制的（Drenckhahn和Pollard 1986），但是解聚速率太慢而不能再生细胞以高达30 μ m/min-1的速率前进所需的单体库（Zigmond 1993）。肌动蛋白解聚因子（ADF/cofilin）是帮助这一过程的理想候选物。它们与肌动蛋白一起定位于细胞的运动区域，并且对于酵母中的细胞活力是必不可少的。线虫、果蝇和网骨藻。在这里，我们描述了这些蛋白质的结构和性质，并强调最近的工作，他们与肌动蛋白的相互作用。
Actin polymerization and cytoskeletal reorganization play an essential role in cell locomotion and many forms of motility, including phagocytosis and cytokinesis. The rate of assembly of actin filaments in vitro is virtually diffusion controlled (Drenckhahn and Pollard 1986), but depolymerization rates are too slow to regenerate the monomer pool required for cells to advance at rates of up to 30llm/min-1 (Zigmond 1993). Actin Depolymerizing Factors (ADF/cofilin) are ideal candidates to aid in this process. They are localized together with actin in motile regions of cells (Fig. 1A) and are essential for cell viability in yeast, C. elegans, Drosophila and Dictyostelium. Here we describe the structure and properties of these proteins and highlight recent work on their interactions with actin.