A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids
A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids
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DOI：
10.1098/rspb.2020.0690
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发表时间：
2020-06-10
影响因子：
4.7
通讯作者：
Larson, Greger
中科院分区：
文献类型：
--
作者：
Allen, Richard;Ryan, Hannah;Larson, Greger
许多进化上不同的哺乳动物物种已经被证明可以产生杂交后代。在某些情况下，F(1)个杂交种能够通过与F(1)个交配产生F(2)个。在其他情况下，由于单性不育，杂交种只能通过与亲本物种回交产生后代（霍尔丹规则）。在这里，我们明确地测试了遗传距离，从线粒体和核基因计算，是否可以作为一个代理来预测由陆地哺乳动物物种之间交配产生的杂交后代的相对生育能力。我们使用一个特征良好的田野混合系统评估了代理的预测能力，并将其应用于现代和古代人类。我们的研究结果揭示了线粒体遗传距离值的小重叠，这区分了计算距离属于两类的物种对：那些杂交后代遵循霍尔丹规则的物种对，以及那些杂交F(1)后代可以产生F(2)s的物种对。遗传距离与杂交育性之间的强相关性表明，这一代理可以用来预测两个哺乳动物物种的杂交后代是否遵循霍尔丹规则。
Numerous pairs of evolutionarily divergent mammalian species have been shown to produce hybrid offspring. In some cases, F(1)hybrids are able to produce F(2)s through matings with F(1)s. In other instances, the hybrids are only able to produce offspring themselves through backcrosses with a parent species owing to unisexual sterility (Haldane's Rule). Here, we explicitly tested whether genetic distance, computed from mitochondrial and nuclear genes, can be used as a proxy to predict the relative fertility of the hybrid offspring resulting from matings between species of terrestrial mammals. We assessed the proxy's predictive power using a well-characterized felid hybrid system, and applied it to modern and ancient hominins. Our results revealed a small overlap in mitochondrial genetic distance values that distinguish species pairs whose calculated distances fall within two categories: those whose hybrid offspring follow Haldane's Rule, and those whose hybrid F(1)offspring can produce F(2)s. The strong correlation between genetic distance and hybrid fertility demonstrated here suggests that this proxy can be employed to predict whether the hybrid offspring of two mammalian species will follow Haldane's Rule.