Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization.
Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization.
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DOI：
10.1158/2159-8290.cd-15-0013
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发表时间：
2015-02
期刊：
影响因子：
28.2
通讯作者：
Nguyen DX
中科院分区：
文献类型：
--
作者：
Arnal-Estapé A;Nguyen DX
糖基化是细胞表面蛋白修饰最主要的形式之一，但其在癌症中的失调以及对肿瘤微环境相互作用的贡献仍然知之甚少。在本期《癌症发现》中，Reticker-Flynn 和 Bhatia 描述了肺癌细胞中的酶开关，该开关触发异常的表面蛋白糖基化模式、粘附到炎症细胞表面的凝集素，以及随后的肝脏转移定植。
Glycosylation is one of the most predominant forms of cell surface protein modifications and yet its de-regulation in cancer and contribution to tumor microenvironment interactions remains poorly understood. In this issue of Cancer Discovery, Reticker-Flynn and Bhatia characterize an enzymatic switch in lung cancer cells that triggers aberrant surface protein glycosylation patterns, adhesion to lectins on the surface of inflammatory cells, and subsequent metastatic colonization of the liver.