Efficacy of azithromycin in a murine toxoplasmosis model, employing a Toxoplasma gondii strain from Turkey
Efficacy of azithromycin in a murine toxoplasmosis model, employing a Toxoplasma gondii strain from Turkey
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DOI：
10.1016/s0001-706x(03)00194-3
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发表时间：
2003-09-01
期刊：
影响因子：
2.7
通讯作者：
Özbilgin, A
中科院分区：
文献类型：
--
作者：
Degerli, K;Kilimcioglu, AA;Özbilgin, A
用Balb/C小鼠建立弓形虫病模型，观察阿奇霉素对弓形虫自然株的治疗和预防作用。首先，建立了7个组--4个研究组和3个对照组--并在第1、2、3、4和7组小鼠体内注射了这种弓形虫天然株的10(3)个速殖子。第1-4组在感染后的不同时间给予阿奇霉素，剂量为100~300 mg/kg/d，连续10天。阿奇霉素200 mg/kg/d及以上预防弓形虫病有效，250 mg/kg/d及以上有效。这些结果表明，阿奇霉素对弓形虫高毒力株的预防和早期感染是有效的，在晚期感染时，它可以使存活时间增加一倍。如果得到进一步的临床研究的支持，阿奇霉素可能成为人类弓形虫病的替代治疗方案。(C)2003爱思唯尔B.V.保留所有权利。
A murine toxoplasmosis model with Balb/C mice was used to investigate the therapeutic and prophylactic efficacy of azithromycin in a native strain of Toxoplasma gondii. Initially, seven groups-four studies and three controls-were established and 10(3) tachyzoites of this native strain of T. gondii were injected intraperitoneally to the mice in groups 1, 2, 3, 4 and 7. Azithromycin was given to groups 1-4 at different times of infection orally between 100 and 300 mg/kg/day for 10 days. Azithromycin was found to be effective at 200 mg/kg/day and above in the prophylaxis, at 250 mg/kg/day and above in the treatment of toxoplasmosis. These results suggest that azithromycin is effective in the prophylaxis and early infection of a highly virulent strain of T. gondii, and it doubled the survival time in the late infection. Azithromycin could be an alternative treatment regimen for human toxoplasmosis, if supported by further clinical investigations. (C) 2003 Elsevier B.V. All rights reserved.