HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody
HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody
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DOI：
10.1016/j.rmed.2011.05.006
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发表时间：
2011-09-01
影响因子：
4.3
通讯作者：
Mishima, Michiaki
中科院分区：
文献类型：
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作者：
Tanizawa, Kiminobu;Handa, Tomohiro;Mishima, Michiaki
背景资料：抗CADM-140抗体（抗CADM-140），也称为抗黑色素瘤分化相关基因5（MDA 5）抗体，是在临床无肌性皮肌炎（C-ADM）患者血清中鉴定的肌炎特异性抗体，与皮肌炎相关间质性肺病（DM-ILD）的预后较差相关。方法：回顾性分析2005年至2009年在京都大学附属医院新诊断的25例DM-ILD患者的高分辨率CT（HRCT）特征。在所有患者首次就诊时测量血清抗CADM-140。治疗前的胸部HRCT图像进行分类的基础上的优势的结果和他们的分布，并比较患者与无antibody.Results：25 DM-ILD患者，12例阳性，13例阴性抗CADM-140。抗CADM-140阳性和阴性患者的HRCT模式存在显着差异（P = 0.002）。抗CADM-140阳性组以低实变或磨玻璃样变（50.0%）和随机型（33.3%）为主，抗CADM-140阴性组以低网状变（69.2%）为主。抗CADM-140阳性病例的显著特征还在于小叶内不存在网状阴影（抗CADM-140（+）为0%，抗CADM-140（-）为84.6%，P < 0.0001）。结论：抗CADM-140阳性DM-ILD的特征在于较低的实变或GGA模式、随机GGA模式和小叶内不存在网状阴影。(C)2011爱思唯尔有限公司保留所有权利。
Background: Anti-CADM-140 antibody (anti-CADM-140), also referred to as anti-melanoma differentiation-associated gene 5 (MDA5) antibody, is a myositis-specific antibody identified in the sera of patients with clinically amyopathic dermatomyositis (C-ADM) and is associated with a worse prognosis in dermatomyositis-associated interstitial lung disease (DM-ILD). We sought to determine high-resolution computed tomography (HRCT) features of DM-ILD with anti-CADM-140.Methods: Twenty-five patients newly diagnosed with DM-ILD at Kyoto University Hospital between 2005 and 2009 were retrospectively reviewed. Serum anti-CADM-140 was measured in all patients at their first visit. Chest HRCT images taken prior to treatment were classified based on the dominant findings and their distribution, and compared between patients with and without the antibody.Results: Of 25 DM-ILD patients, 12 were positive and 13 were negative for anti-CADM-140. HRCT patterns differed significantly between anti-CADM-140-positive and negative patients (P = 0.002). Lower consolidation or ground-glass attenuation (GGA) pattern (50.0%) and random GGA pattern (33.3%) were the predominant patterns in anti-CADM-140-positive cases, while lower reticulation pattern (69.2%) was frequently seen in anti-CADM-140-negative Cases. Anti-CADM-140-positive cases were also significantly characterized by the absence of intralobular reticular opacities (0% in anti-CADM-140 (+) vs. 84.6% in anti-CADM-140 (-), P < 0.0001).Conclusions: Anti-CADM-140-positive DM-ILD was characterized by lower consolidation or GGA pattern, random GGA pattern, and the absence of intralobular reticular opacities. (C) 2011 Elsevier Ltd. All rights reserved.