Comparative genomic hybridisation of ductal carcinoma in situ of the breast: Identification of regions of DNA amplification and deletion in common with invasive breast carcinoma
Comparative genomic hybridisation of ductal carcinoma in situ of the breast: Identification of regions of DNA amplification and deletion in common with invasive breast carcinoma
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DOI：
10.1038/sj.onc.1200923
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发表时间：
1997-03-06
期刊：
影响因子：
8
通讯作者：
Varley, JM
中科院分区：
文献类型：
--
作者：
James, LA;Mitchell, ELD;Varley, JM
比较基因组杂交已被用来映射拷贝数的变化，在9例乳腺导管癌原位蜡包埋档案材料。结果显示，1q、17 q、19 q、20 p和20 q的异常区增多，13 q、14 q、17 p、16 q和22 q的异常区丢失。10p、8q和20q区域的扩增也被观察到，染色体改变在较高级别的DCIS中更频繁，并且与先前使用相同技术在浸润性乳腺癌中检测到的那些非常相似。这些数据为DCIS是浸润性乳腺癌的前驱病变的观点提供了强有力的分子支持。
Comparative genomic hybridisation has been used to map copy number changes in nine cases of ductal carcinoma in situ of the breast obtained from wax-embedded archive material. A wide variety of abnormalities were detected including gain of regions of 1q, 17q, 19q, 20p and 20q and loss on 13q, 14q, 17p, 16q and 22q. Amplification of areas on 10p, 8q and 20q were also observed, Chromosomal alterations were more frequent in higher grade DCIS and closely resemble those previously detected in invasive breast cancer using the same technique. These data provide strong molecular support for the view that DCIS is a precursor lesion of invasive breast carcinoma.