Plasma sex hormone levels and mortality in disabled older men and women
Plasma sex hormone levels and mortality in disabled older men and women
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DOI：
10.1111/j.1447-0594.2010.00670.x
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发表时间：
2011-04-01
影响因子：
3.3
通讯作者：
Ouchi, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Fukai, Shiho;Akishita, Masahiro;Ouchi, Yasuyoshi
目的：探讨循环性激素水平和随后的死亡率之间的关系，在残疾elderic.Methods：这项前瞻性观察性研究是由214老年受试者年龄在70-96岁（117名男性和97名女性，平均+/-标准差年龄，83 +/- 7岁），接受长期护理设施在长野，日本。基线血浆性激素水平的全因死亡率measured.Results：排除死亡后，在前6个月，27例男性死亡和28例女性死亡发生在平均随访32个月和45个月（最多52个月），分别。死亡率在高和低睾酮三分位数的男性之间有显著差异，但在中和低三分位数之间没有显著差异。与中三分位数和高三分位数的受试者相比，睾酮水平低三分位数（< 300 ng/dL）的男性更容易死亡，与年龄、营养状况、功能状况和慢性疾病无关（风险比[HR] = 3.27，95%置信区间[CI] = 1.24-12.91）。相反，低脱氢表雄酮硫酸盐（DHEA-S）三分位数与女性较高的死亡风险相关（多变量校正HR = 4.42，95%CI = 1.51-12.90）。排除第一年的死亡和癌症死亡对这些结果的影响很小。DHEA-S水平的男性和睾酮和雌二醇水平的妇女没有相关的mortality.Conclusion：低睾酮的男性和低DHEA-S的妇女接受护理设施与死亡风险增加，独立于其他危险因素和预先存在的健康状况。Geriatr Gerontol Int 2011; 11：196-203.
Aim:To investigate the relationship between circulating sex hormone levels and subsequent mortality in disabled elderly.Methods:This prospective observational study was comprised of 214 elderly subjects aged 70-96 years (117 men and 97 women; mean +/- standard deviation age, 83 +/- 7 years), receiving services at long-term care facilities in Nagano, Japan. All-cause mortality by baseline plasma sex hormone levels was measured.Results:After excluding deaths during the first 6 months, 27 deaths in men and 28 deaths in women occurred during a mean follow up of 32 months and 45 months (up to 52 months), respectively. Mortality rates differed significantly between high and low testosterone tertiles in men, but did not differ significantly between middle and low tertiles. Compared with subjects in the middle and high tertiles, men with testosterone levels in the low tertile (< 300 ng/dL) were more likely to die, independent of age, nutritional status, functional status and chronic disease (hazard ratio [HR] = 3.27, 95% confidence interval [CI] = 1.24-12.91). In contrast, the low dehydroepiandrosterone sulfate (DHEA-S) tertile was associated with higher mortality risk in women (multivariate adjusted HR = 4.42, 95% CI = 1.51-12.90). Exclusion of deaths during the first year and cancer deaths had minimal effects on these results. DHEA-S level in men and testosterone and estradiol levels in women were not related to mortality.Conclusion:Low testosterone in men and low DHEA-S in women receiving care at facilities are associated with increased mortality risk, independent of other risk factors and pre-existing health conditions. Geriatr Gerontol Int 2011; 11: 196-203.