Expression of Polypeptide N-Acetylgalactosaminyl Transferase-3 and Its Association with Clinicopathological Factors in Thyroid Carcinomas
Expression of Polypeptide N-Acetylgalactosaminyl Transferase-3 and Its Association with Clinicopathological Factors in Thyroid Carcinomas
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DOI：
10.1089/thy.2012.0613
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发表时间：
2013-12-01
期刊：
影响因子：
6.6
通讯作者：
Amano, Jun
中科院分区：
文献类型：
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作者：
Mochizuki, Yasuhiro;Ito, Ken-ichi;Amano, Jun
背景资料：多肽N-乙酰氨基半乳糖转移酶-3（GalNAc-T3）已报道在几种人类腺癌中表达，并与肿瘤的临床病理特征相关。我们研究了GalNAc-T3在甲状腺癌中的临床病理意义。研究方法：我们使用特异性抗体评估了167例甲状腺癌患者中GalNAc-T3的表达，并分析了其表达与临床病理特征之间的相关性。结果：GalNAc-T3在85.8%的正常卵泡上皮细胞中表达。乳头状癌101例（73.7%）呈阳性表达。乳头状癌高分化成分（乳头状和滤泡状）的阳性率显著高于低分化成分（小梁状和实性）（p
Background: Polypeptide N-acetylgalactosaminyl transferase-3 (GalNAc-T3) has been reportedly expressed in several human adenocarcinomas and is associated with clinicopathological features of tumors. We investigated the clinicopathological significance of GalNAc-T3 in thyroid cancer. Methods: We evaluated the expression of GalNAc-T3 in 167 patients with thyroid cancer using a specific antibody and analyzed the association between its expression and clinicopathological features. Results: GalNAc-T3 was expressed in 85.8% of normal follicular epithelial cells. In papillary carcinomas, positive staining was observed in 101 (73.7%) cases. Well-differentiated components (papillary and follicular) of papillary carcinomas were significantly more frequently positive than poorly differentiated components (trabecular and solid) (p