Meta-Analysis: Diagnostic Accuracy of Anti-Carbamylated Protein Antibody for Rheumatoid Arthritis.
Meta-Analysis: Diagnostic Accuracy of Anti-Carbamylated Protein Antibody for Rheumatoid Arthritis.
复制标题
DOI：
10.1371/journal.pone.0159000
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Li L;Deng C;Chen S;Zhang S;Wu Z;Hu C;Zhang F;Li Y
抗氨甲酰化蛋白 (CarP) 抗体是一种新型生物标志物，可能有助于诊断类风湿性关节炎 (RA)。我们的目的是评估抗 CarP 抗体对 RA 的诊断价值。我们系统地检索了 PubMed、Embase、Cochrane 图书馆、Web of Science 和 Scopus 中截至 2015 年 12 月 15 日发表的研究。其中包括评估抗 CarP 抗体在 RA 诊断中的效用的任何语言的研究，其中健康捐献者或没有关节炎或关节痛的患者作为对照。两名研究人员独立评估研究的纳入情况、评估研究质量并提取数据。使用双变量混合效应模型总结了 7 项符合条件的研究的诊断指标。抗 CarP 抗体的汇总敏感性、特异性以及阳性和阴性似然比分别为 42%（95% CI，38% 至 45%）、96%（95% CI，95% 至 97%）、10.2（95% CI，7.5 至 13.9）和 0.61（95% CI，0.57 至 0.65）。总结诊断优势比为 17（95% CI，12 至 24），总结受试者工作特征曲线下面积为 80%（95% CI，77% 至 84%）。抗CarP抗体对RA的诊断价值中等，特异性较高，但敏感性较低。
The anti-carbamylated protein (CarP) antibody is a novel biomarker that might help in the diagnosis of rheumatoid arthritis (RA). We aim to assess the diagnostic value of anti-CarP antibody for RA. We systematically searched PubMed, Embase, the Cochrane Library, Web of Science, and Scopus for studies published by December 15, 2015. Studies in any language that evaluated the utility of the anti-CarP antibody in the diagnosis of RA in which healthy donors or patients without arthritis or arthralgia served as controls were included. Two investigators independently evaluated studies for inclusion, assessed study quality and abstracted data. A bivariate mixed-effects model was used to summarize the diagnostic indexes from 7 eligible studies. The pooled sensitivity, specificity, and positive and negative likelihood ratios for anti-CarP antibody were 42% (95% CI, 38% to 45%), 96% (95% CI, 95% to 97%), 10.2 (95% CI, 7.5 to 13.9), and 0.61 (95% CI, 0.57 to 0.65), respectively. The summary diagnostic odds ratio was 17 (95% CI, 12 to 24), and the area under summary receiver operator characteristic curve was 80% (95% CI, 77% to 84%). Anti-CarP antibody has a moderate value in the diagnosis of RA with high specificity but relatively low sensitivity.