Cerebrospinal fluid viral load is related to cortical atrophy and not to intracerebral calcifications in children with symptomatic HIV disease
Cerebrospinal fluid viral load is related to cortical atrophy and not to intracerebral calcifications in children with symptomatic HIV disease
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DOI：
10.3109/13550280009018303
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发表时间：
2000-10-01
影响因子：
3.2
通讯作者：
Sei, S
中科院分区：
文献类型：
--
作者：
Brouwers, P;Civitello, L;Sei, S
对39例0.5~13岁有症状的HIV-1患儿的血浆和脑脊液病毒载量与CT脑扫描异常的关系进行了研究。用定量RNA聚合酶链式反应检测HIV-1RNA水平，用半定量模拟评分技术评估非增强CT脑扫描。脑脊液HIV-1RNA拷贝数与皮质萎缩严重程度的CT脑扫描评分显著相关(r=0.36；P
The relationships between viral load in plasma and cerebrospinal fluid (CSF) and computed tomography (CT) brain scan abnormalities were studied in 39 children between 0.5 and 13 years of age with symptomatic HIV-1 disease. Quantitative RNA PCR was used to determine HIV-1 RNA levels and a semiquantitative analog rating technique was used to evaluate non-contrast CT brain scans. CSF HIV-1 RNA copy number correlated significantly with CT brain scan ratings for severity of cortical atrophy (r=0.36; P