Expanding the spectrum of neuronal pathology in multiple system atrophy
Expanding the spectrum of neuronal pathology in multiple system atrophy
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DOI：
10.1093/brain/awv114
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发表时间：
2015-08-01
期刊：
影响因子：
14.5
通讯作者：
Parisi, Joseph E.
中科院分区：
文献类型：
--
作者：
Cykowski, Matthew D.;Coon, Elizabeth A.;Parisi, Joseph E.
多系统萎缩（MSA）的临床特征是帕金森病、小脑功能障碍和自主神经功能障碍，病理特征是神经胶质细胞质包涵体。 Cykowski 等人利用 35 名患者的病理和临床数据。扩大了 MSA 神经元病理学的范围，并认为神经元包涵体在疾病发病机制中发挥着关键作用。有关本文的科学评论，请参阅 Halliday (doi:10.1093/brain/awv151)。多系统萎缩 (MSA) 的临床特征为帕金森病、小脑功能障碍和自主神经功能障碍，病理学特征为神经胶质细胞 细胞质内含物。 Cykowski 等人利用 35 名患者的病理和临床数据。扩大了 MSA 神经元病理学的范围，并认为神经元包涵体在疾病发病机制中发挥着关键作用。有关本文的科学评论，请参阅 Halliday (doi:10.1093/brain/awv151)。
Multiple system atrophy (MSA) is characterized clinically by parkinsonism, cerebellar dysfunction, and dysautonomia, and pathologically by glial cytoplasmic inclusions. Using pathological and clinical data from 35 patients, Cykowski et al. expand the spectrum of neuronal pathology in MSA and argue that neuronal inclusions have a key role in disease pathogenesis.See Halliday (doi:10.1093/brain/awv151) for a scientific commentary on this article.Multiple system atrophy (MSA) is characterized clinically by parkinsonism, cerebellar dysfunction, and dysautonomia, and pathologically by glial cytoplasmic inclusions. Using pathological and clinical data from 35 patients, Cykowski et al. expand the spectrum of neuronal pathology in MSA and argue that neuronal inclusions have a key role in disease pathogenesis.See Halliday (doi:10.1093/brain/awv151) for a scientific commentary on this article.