The effect of rapid HIV-1 testing on uptake of perinatal HIV-1 interventions: a randomized clinical trial
The effect of rapid HIV-1 testing on uptake of perinatal HIV-1 interventions: a randomized clinical trial
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DOI：
10.1097/00002030-200301030-00015
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发表时间：
2003-01-03
期刊：
影响因子：
3.8
通讯作者：
Stewart, GCJ
中科院分区：
文献类型：
--
作者：
Malonza, IA;Richardson, BA;Stewart, GCJ
目的：我们研究了是否使用快速检测HIV-1检测增加孕妇获得HIV-1结果的比例和围产期HIV-1 interventions.Methods：孕妇参加公共卫生诊所在内罗毕提供自愿咨询和HIV-1检测。接受艾滋病病毒检测的妇女被随机分配接受快速或传统的艾滋病病毒-1检测。被随机分配到快速检测的妇女被允许在同一天收到结果或稍后返回。随机分配到传统的酶联免疫吸附试验（ELISA）测试的妇女的结果是7天后可用。结果：在1282名自愿接受HIV-1检测和咨询的妇女中，1249人接受了检测，其中627人被随机分配到快速检测组，622人被随机分配到常规检测组。接受快速检测的妇女从检测到获得结果的中位时间为0天，而接受常规检测的妇女为11天。与常规检测相比，接受快速检测的妇女获得艾滋病毒-1检测结果的百分比明显较高。在161名艾滋病毒-1血清反应呈阳性的妇女中，只有24人接受了抗逆转录病毒预防。围产期HIV-1干预措施的摄取没有差异之间的HIV-1血清反应阳性的妇女随机分配到快速检测或常规ELISA testing.Conclusion：快速HIV-1检测显着增加了妇女接受HIV-1的结果，这是重要的性和围产期HIV-1预防的比例。目前的挑战仍然是提高艾滋病毒1血清反应阳性妇女对围产期艾滋病毒1干预措施的接受率。(C)2003年利平科特威廉姆斯威尔金斯。
Objective: We examined whether HIV-1 testing using a rapid assay increases the proportion of pregnant women obtaining HIV-1 results and the uptake of perinatal HIV-1 interventions.Methods: Pregnant women attending public health clinics in Nairobi were offered voluntary counselling and testing for HIV-1. Consenting women were randomly assigned to receive either rapid or conventional HIV-1 testing. Women randomly assigned to rapid testing were allowed to receive same-day results or to return later. The results for women randomly assigned to conventional enzyme-linked immunosorbent assay (ELISA) testing were available after 7 days. HIV-1-infected women were referred for antiretroviral prophylaxis to prevent mother-to-child transmission of HIV-1.Results: Among 1282 women offered voluntary HIV-1 testing and counselling, 1249 accepted testing, of whom 627 were randomly assigned to rapid testing and 622 to conventional testing. The median duration between testing and obtaining results was 0 days for women who received rapid testing compared with 11 days for women who received conventional testing. The percentage receiving HIV-1 results was significantly higher among women who received rapid testing compared with conventional testing. Of 161 HIV-1-seropositive women, only 24 received antiretroviral prophylaxis. The uptake of perinatal HIV-1 interventions did not differ between HIV-1-seropositive women randomly assigned to rapid testing or conventional ELISA testing.Conclusion: Rapid HIV-1 testing significantly increased the proportion of women receiving HIV-1 results, which is important for sexual and perinatal HIV-1 prevention. The challenge remains to improve the uptake of perinatal HIV-1 interventions among HIV-1-seropositive women. (C) 2003 Lippincott Williams Wilkins.