Obesity affects the biopsy-mediated detection of prostate cancer, particularly high-grade prostate cancer: a dose-response meta-analysis of 29,464 patients.
Obesity affects the biopsy-mediated detection of prostate cancer, particularly high-grade prostate cancer: a dose-response meta-analysis of 29,464 patients.
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DOI：
10.1371/journal.pone.0106677
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Ding Q
中科院分区：
文献类型：
--
作者：
Hu MB;Liu SH;Jiang HW;Bai PD;Ding Q
在以前的研究中，肥胖（根据身体质量指数测量）与活检测量的前列腺癌，特别是高级别前列腺癌的风险不一致。本荟萃分析旨在阐明这些相关性。对截至2014年1月发表的相关研究在MEDLINE和EMBASE数据库中进行了全面的文献检索。采用随机效应分析方法，采用STATA软件进行Meta分析。共确定了11项研究，包括29，464名个体。体重指数增加5 kg/m2与前列腺癌检出风险增加15%（OR，1.15; 95%CI，0.98-1.34）和活检时高级别前列腺癌检出风险增加37%（OR，1.37; 95%CI，1.19-1.57）相关。在美国、欧洲或亚洲进行的研究结果之间没有差异。我们还发现，调整了前列腺特异性抗原水平、直肠指检结果和前列腺体积的研究获得了积极的显著结果（OR，1.27; 95%CI，1.12-1.44），而没有调整上述混杂变量的研究获得了阴性结果（OR，0.92; 95%CI，0.68-1.25）。此外，随着活检芯数量的增加，体重指数与前列腺癌和高级别疾病检测之间的正相关性趋于增强。目前的荟萃分析表明，高体重指数与前列腺癌检出呈正相关，特别是高级别前列腺癌检出。建议对肥胖人群采用改良的、可能更积极的活检策略。
In previous studies, obesity (measured according to the body mass index) has correlated inconsistently with the risk of biopsy-measured prostate cancer, and specifically high-grade prostate cancer. This meta-analysis aimed to clarify these correlations. A comprehensive literature search of the MEDLINE and EMBASE databases was conducted for relevant studies published through January 2014. The pooled estimates of odds ratios (OR) and confidence intervals (CI) were computed, and the meta-analysis was performed with the STATA software according to a random effects approach. A total of 11 studies that included 29,464 individuals were identified. A 5-kg/m2 increase in body mass index was associated with a 15% (OR, 1.15; 95% CI, 0.98–1.34) higher risk of prostate cancer detection and a 37% (OR, 1.37; 95% CI, 1.19–1.57) higher risk of high-grade prostate cancer detection at biopsy. There were no differences among the results of studies conducted in the USA, Europe or Asia. We also found that studies that had adjusted for prostate-specific antigen levels, digital rectal examination results, and prostate volumes obtained positive significant outcomes (OR, 1.27; 95% CI, 1.12–1.44), whereas studies that did not adjust for the above-mentioned confounding variables obtained negative results (OR, 0.92; 95% CI, 0.68–1.25). Moreover, the positive correlation between body mass index and the detection of both prostate cancer and high-grade diseases tended to be stronger as the number of biopsy cores increased. The present meta-analysis demonstrated that a high body mass index correlated positively with prostate cancer detection, especially high-grade prostate cancer detection. The adoption of a modified and possibly more aggressive biopsy strategy was suggested for obese populations.
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DOI：
10.4111/kju.2012.53.9.593
发表时间：
2012-09
期刊：
Korean journal of urology
影响因子：
--
作者：
Jeon KP;Jeong TY;Lee SY;Hwang SW;Shin JH;Kim DS
通讯作者：
Kim DS
影响因子：
158.5
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
2.1
作者：
Freedland, Stephen J.;Wen, Joanne;Aronson, William J.
通讯作者：
Aronson, William J.
影响因子：
2
作者：
Higgins, JPT;Thompson, SG
通讯作者：
Thompson, SG
影响因子：
8.9
作者：
Ashwell, M.;Gunn, P.;Gibson, S.
通讯作者：
Gibson, S.