Effects of initiation of 3'-azido,3'-deoxythymidine (zidovudine) treatment at different times after infection of rhesus monkeys with simian immunodeficiency virus.
Effects of initiation of 3'-azido,3'-deoxythymidine (zidovudine) treatment at different times after infection of rhesus monkeys with simian immunodeficiency virus.
复制标题
恒河猴感染猿猴免疫缺陷病毒后不同时间开始3-叠氮，3-脱氧胸苷（齐多夫定）治疗的效果。
DOI：
10.1093/infdis/168.4.825
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Baskin,GB
中科院分区：
文献类型：
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作者：
Martin,LN;Murphey-Corb,M;Soike,KF;Davison-Fairburn,B;Baskin,GB
本文观察了恒河猴接种猴免疫缺陷病毒（SIV）后不同时间用齐多夫定（ZIDO）开始治疗的效果。在静脉内接种10 ID 50的SIV后1、8、24或72 h，开始100 mg/kg/天（25 mg/kg，皮下注射，每6 h一次）的齐多夫定治疗。处理持续28天，并将结果与盐水处理的对照组进行比较。接种后14天（AI）的血清感染性病毒滴度显着下降后，治疗开始1，8，或24小时AI。滴度与治疗开始时间相关。1-72小时AI开始的治疗可防止持续性SIV抗原血症的建立;早期开始治疗观察到更大的效果。治疗开始1-8小时AI导致病毒抗原血症水平下降14天AI和延迟的CD 4 + CD 29+血淋巴细胞减少。较早开始治疗导致抗原血症复发延迟，生存期延长。在已知暴露的情况下，早期开始治疗对于限制初始病毒复制和传播可能很重要。
The effects of initiating treatment with 3′-azido-3′-deoxythymidine (zidovudine) at different times after inoculation of simian immunodeficiency virus (SIV) were investigated in rhesus monkeys. Zidovudine treatments of 100 mg/kg/day (25 mg/kg, subcutaneously every 6 h) were initiated 1, 8, 24, or 72 h after intravenous inoculation of 10 ID50ofSIV. Treatments continued for 28 days, and results were compared with those of saline-treated controls. Serum infectious virus titers 14 days after inoculation (AI) significantly decreased after treatment initiation 1, 8, or 24 h AI. Titers were correlated with the time treatment was initiated. Treatments initiated 1–72 h AI prevented the establishment of persistent SIV antigenemia; greater effects were observed with earlier initiation of treatment. Treatments initiated 1–8 h AI resulted in decreased levels of viral antigenemia 14 days AI and delayed decreases in CD4+CD29+blood lymphocytes. Earlier treatment initiation resulted in delayed recurrence of antigenemia, with a tendency for longer survival. Early initiation of treatment may be important for limiting initial viral replication and dissemination in cases of known exposure.