Effects of dopamine on carotid chemo‐ and baroreceptors in vitro.
Effects of dopamine on carotid chemo‐ and baroreceptors in vitro.
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DOI：
10.1113/jphysiol.1975.sp010794
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
P. Zapata
中科院分区：
文献类型：
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作者：
P. Zapata
1.多巴胺对源自动脉化学感受器和压力感受器的感觉放电的影响是在体外使用从麻醉猫切除的颈动脉体或窦并用洛克氏溶液灌注来研究的。2.流内注射多巴胺10-200 μ g产生化学感受器放电频率的短暂抑制。在20份制备液中的18份首次注射后观察到该效应。3.多巴胺的抑制作用可以部分或全部抵消同时应用乙酰胆碱或氰化物引起的化学感受器兴奋。4.多巴胺的这种抑制作用可通过多巴胺能（螺哌利多）或α-肾上腺素能（二苯丁胺）阻滞剂预处理而降低或消除。5.在短时间间隔内重复注射多巴胺后，抑制作用被双相作用（早期抑制，随后是晚期兴奋）、晚期和持久的兴奋或化学感受器活性无变化所取代。多巴胺的晚期兴奋作用不被多巴胺能或α-肾上腺素能阻滞剂阻断。6.去甲肾上腺素不影响灌注的颈动脉体的化学感受器活性。DL-多巴只会引起迟发性和持久性兴奋效应。7.在颈动脉窦制剂中，多巴胺引起压力感受器放电频率微弱但持久的增加。8.它的结论是，多巴胺可能发挥调节作用，通过当地的监管过程中产生的化学感受器活动。
1. The effects of dopamine on the sensory discharges originating from arterial chemo‐ and baroreceptors were studied in vitro using carotid bodies or sinuses excised from anaesthetized cats and superfused with Locke's solution. 2. Intrastream injections of dopamine 10–200 mug produced a transient depression of the frequency of chemoreceptor discharges. This effect was observed in response to the first injection in eighteen out of twenty preparations. 3. The inhibitory effect of dopamine can counteract partially or totally the excitation of chemoreceptors evoked by simultaneous application of acetylcholine or cyanide. 4. This inhibitory effect of dopamine is reduced or abolished by pretreatment with dopaminergic (Spiroperidol) or alpha‐adrenergic (Dibenamine) blockers. 5. In response to repeated injections of dopamine applied at short intervals, the inhibitory effect is replaced by a biphasic effect (early inhibition followed by late excitation), a late and long‐lasting excitation or no changes in chemoreceptor activity. The late excitatory effects of dopamine are not blocked by dopaminergic or alpha‐adrenergic blockers. 6. Noradrenaline does not affect the chemoreceptor activity of the superfused carotid body. DL‐DOPA induces only a late and long‐lasting excitatory effect. 7. In carotid sinus preparations, dopamine induces a weak but long‐lasting increase in the frequency of baroreceptor discharges. 8. It is concluded that dopamine may play a modulatory role in the generation of chemoreceptor activity through local regulatory processes.