BILE-SALT INHIBITION OF MOTILITY IN THE ISOLATED PERFUSED RABBIT TERMINAL ILEUM
BILE-SALT INHIBITION OF MOTILITY IN THE ISOLATED PERFUSED RABBIT TERMINAL ILEUM
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DOI：
10.1136/gut.34.4.483
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发表时间：
1993-04-01
期刊：
影响因子：
24.5
通讯作者：
BALLANTYNE, GH
中科院分区：
文献类型：
--
作者：
ARMSTRONG, DN;KRENZ, HK;BALLANTYNE, GH
在离体灌流的家兔回肠末端研究了胆汁对小肠运动的影响。有人提出，将胆汁输送到回肠远端会通过肽YY（PYY）释放抑制回肠运动活动，因此检查了管腔胆汁对运动活动的影响，并测量了PYY释放。管腔胆汁和牛磺熊去氧胆酸（10 mmol）抑制回肠运动活动。从胆汁静脉流出物的动脉输注抑制回肠抑制运动活动在第二个孤立的回肠。这表明存在回肠运动活性的体液抑制剂。管腔胆汁增加静脉PYY浓度（42.5（8.5）至502（46-2）pmol/l; p
The effects of bile on small bowel motility were studied in isolated, perfused rabbit terminal ileum. It was proposed that bile delivery into the distal ileum would inhibit ileal motor activity, by peptide YY (PYY) release and therefore the effect of luminal bile on motor activity was examined and PYY release measured. Luminal bile and taurocheodeoxycholic acid (10 mmol) inhibited ileal motor activity. Arterial infusion of venous effluents from a bile inhibited ileum suppressed motor activity in a second isolated ileum. This shows the presence of a humoral inhibitor of ileal motor activity. Luminal bile increased venous PYY concentrations (42.5 (8.5) to 502 (46-2) pmol/l; p