On the opening mechanism of the aortic valve: Some observations from simulations.
On the opening mechanism of the aortic valve: Some observations from simulations.
复制标题
DOI：
10.1080/0309190031000096621
复制
发表时间：
2003-11-01
影响因子：
--
通讯作者：
Yoxall, A.
中科院分区：
文献类型：
--
作者：
Howard, I. C.;Patterson, E. A.;Yoxall, A.
从机械工程设计的角度来看，主动脉瓣令人印象深刻。然而，我们对它的力学的理解是有限的，我们无法研究其在体内的功能密切和详细。计算机模拟方法提供了一种替代方法，并描述了构建更完整的心脏模型的第一步。该模型包括主动脉瓣，它的小叶和他们的支持根，和窦建模为非线性材料。一个显式的有限元代码已被用来检查随时间变化的位移的结构，受到压力分布，其中包括左心室，主动脉和胸腔压力。结果表明，瓣膜瓣叶通过径向根部扩张和血流方向瓣叶运动的组合打开。将其与主动脉根部明显变硬的模型进行比较，发现这种改良瓣膜通过瓣叶折叠打开，从而获得小得多的瓣口。这些发现，关于根扩展的重要性，是在早期的实验观察。
Viewed from the standpoint of mechanical engineering design, the aortic valve is impressive. However, our understanding of its mechanics is limited by our inability to study its in vivo function closely and in detail. Computer simulation methods offer an alternative approach and a first step towards the construction of a more complete cardiac model is described. The model includes the aortic valve, its leaflets and their supporting root, and the sinuses modelled as nonlinear materials. An explicit finite element code has been used to examine the time-varying displacements of the structure that was subject to pressure distributions, which included left ventricular, aortic and thoracic pressures. It was shown that the leaflets of the valve open by a combination of root expansion in a radial direction and leaflet movement in the direction of blood flow. This was compared to a model in which the aortic root was stiffened significantly, and it was found that this modified valve opened by leaflet folding to give a much smaller orifice. These findings, concerning the importance of root expansion, are in agreement with earlier experimental observations.