Vascular-Derived Vegfa Promotes Cortical Interneuron Migration and Proximity to the Vasculature in the Developing Forebrain.
Vascular-Derived Vegfa Promotes Cortical Interneuron Migration and Proximity to the Vasculature in the Developing Forebrain.
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DOI：
10.1093/cercor/bhy082
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发表时间：
2018-07-01
期刊：
影响因子：
--
通讯作者：
Parnavelas JG
中科院分区：
文献类型：
--
作者：
Barber M;Andrews WD;Memi F;Gardener P;Ciantar D;Tata M;Ruhrberg C;Parnavelas JG
血管内皮生长因子（Vegfa）是促进胚胎小鼠前脑血管形成的重要因子。此外，它直接影响神经发育，尽管它在前脑形成中的作用还不太清楚。最近提出Vegfa可能影响GABA能中间神经元的发育，中间神经元是在皮质神经元回路中具有关键信号传导作用的抑制性细胞。然而，它影响中间神经元发育的机制仍然未知。在这里，我们研究了Vegfa可能影响皮层中间神经元发育的发育过程，通过分析普遍表达Vegfa 120亚型的转基因小鼠来扰乱其信号梯度。我们发现，尽管异常的血管网络，中间神经元到达背侧皮质在中期阶段的皮质。相反，内皮消融Vegfa改变了皮质中间神经元的数量，它们在皮质内的分布和与血管的空间接近度。我们首次表明，血管分泌的指导因子促进早期迁移的中间神经元在完整的前脑在体内，并确定一个新的作用vascular-Vegfa在这个过程中。
Vascular endothelial growth factor (Vegfa) is essential for promoting the vascularization of the embryonic murine forebrain. In addition, it directly influences neural development, although its role in the forming forebrain is less well elucidated. It was recently suggested that Vegfa may influence the development of GABAergic interneurons, inhibitory cells with crucial signaling roles in cortical neuronal circuits. However, the mechanism by which it affects interneuron development remains unknown. Here we investigated the developmental processes by which Vegfa may influence cortical interneuron development by analyzing transgenic mice that ubiquitously express the Vegfa120 isoform to perturb its signaling gradient. We found that interneurons reach the dorsal cortex at mid phases of corticogenesis despite an aberrant vascular network. Instead, endothelial ablation of Vegfa alters cortical interneuron numbers, their intracortical distribution and spatial proximity to blood vessels. We show for the first time that vascular-secreted guidance factors promote early-migrating interneurons in the intact forebrain in vivo and identify a novel role for vascular-Vegfa in this process.
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DOI：
10.1002/cne.23806
发表时间：
2016-02-15
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Andrews WD;Davidson K;Tamamaki N;Ruhrberg C;Parnavelas JG
通讯作者：
Parnavelas JG
影响因子：
3.3
作者：
Ferrara N
通讯作者：
Ferrara N
影响因子：
3
作者：
Cain, Jacob T.;Berosik, Matthew A.;Snyder, Stephanie D.;Crawford, Natalie F.;Nour, Shirin I.;Schaubhut, Geoffrey J.;Darland, Diane C.
通讯作者：
Darland, Diane C.
DOI：
10.1242/dev.063362
发表时间：
2011-09
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Cariboni A;Davidson K;Dozio E;Memi F;Schwarz Q;Stossi F;Parnavelas JG;Ruhrberg C
通讯作者：
Ruhrberg C
影响因子：
3.7
作者：
Lazarus, Matthew S.;Krishnan, Keerthi;Huang, Z. Josh
通讯作者：
Huang, Z. Josh