Simultaneous Inference

Simultaneous Inference
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DOI:
10.1002/0470011815.b2a15148
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发表时间:
2020
期刊:
Biostatistics Decoded
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通讯作者:
Peter C. O'Brien
Peter C. O'Brien
中科院分区:
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文献类型:
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作者:
Nancy L. Geller;Peter C. O'Brien

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Bonferroni联合置信区间将单个参数的置信系数调整为较高的1 \(\alpha \),以便参数集合的置信系数必须至少为1 \(\alpha \)。这是基于以下不等式:定理(Bonferroni不等式)\[P(\beta_0\cap\beta_1)\geq1-P(\beta_0^c)-P(\beta_1^c)\label{Bonferroni}\]对于任何两个事件\(\beta_0 \)和\(\beta_1 \),其中\(\beta_0^c \)和\(\beta_1^c \)分别是事件\(\beta_0 \)和\(\beta_1 \)的补充。我们采取,(\beta_0 =\)事件的置信区间(\beta_0 \)覆盖\(\beta_0 \);并且,\(\beta_1 =\)事件的置信区间(\beta_1 \)覆盖\(\beta_1 \);所以,如果\(P(\beta_0)= 1-\alpha_1\),且(P(\beta_1)= 1-\alpha_2 \),然后\(P(\beta_0\cap\beta_1)\geq1-\alpha_1-\alpha_2 \),通过Bonferroni不等式(等式\ref{Bonferroni})。请注意,\(\beta_0\cap\beta_1\)是两个参数的置信区间覆盖各自参数的事件。因此,我们取\(\alpha_1 = \alpha_2 = \alpha/2 \),得到置信系数至少为\(1 \alpha \)的联合置信区间,\(\beta_0\)和\(\beta_1\)分别为\(b_0 \pm t(1-\alpha/4; n-2)s(b_0)\)和\(b_1 \pm t(1-\alpha/4;n-2)s(b_1)\)。
Bonferroni Joint Confidence Intervals The confidence coefficients for individual parameters are adjusted to the higher 1 \( \alpha \) so that the confidence coefficient for the collection of parameters must be at least 1 \( \alpha \). This is based on the following inequality: Theorem (Bonferroni's Inequality) \[P( \beta_0\cap\beta_1)\geq1-P(\beta_0^c)-P(\beta_1^c) \label{Bonferroni}\] for any two events \(\beta_0 \) and \( \beta_1 \), where \(\beta_0^c \) and \(\beta_1^c \) are complements of events \( \beta_0 \) and \( \beta_1 \), respectively. We take, \( \beta_0 =\) the event that confidence interval for \(\beta_0 \) covers \(\beta_0 \); and, \( \beta_1 =\) the event that confidence interval for \( \beta_1 \) covers \( \beta_1 \); So, if \(P(\beta_0) = 1-\alpha_1 \), and \(P(\beta_1) = 1-\alpha_2 \), then \(P(\beta_0\cap\beta_1)\geq1-\alpha_1-\alpha_2 \), by Bonferroni's inequality (Equation \ref{Bonferroni}). Note that \(\beta_0\cap\beta_1\) is the event that confidence intervals for both the parameters cover the respective parameters. Therefore we take \(\alpha_1 = \alpha_2 = \alpha/2 \) to get joint confidence intervals with confidence coefficient at least \(1 \alpha \), \(b_0 \pm t(1-\alpha/4;n-2) s(b_0) \) and \(b_1 \pm t(1-\alpha/4;n-2) s(b_1) \) for \(\beta_0\) and \(\beta_1\), respectively.