Electromagnetic fields, such as those from mobile phones, alter regional cerebral blood flow and sleep and waking EEG
Electromagnetic fields, such as those from mobile phones, alter regional cerebral blood flow and sleep and waking EEG
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DOI：
10.1046/j.1365-2869.2002.00314.x
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发表时间：
2002-12-01
影响因子：
4.4
通讯作者：
Achermann, P
中科院分区：
文献类型：
--
作者：
Huber, R;Treyer, V;Achermann, P
移动电话的使用正在迅速增加，但关于电磁场（EMF）暴露对大脑生理可能产生的影响的数据有限。我们研究了电磁场与假对照暴露对人类清醒区域脑血流量（rCBF）和清醒和睡眠脑电图（EEG）的影响。实验1，在单侧头部暴露于脉冲调制900 MHz电磁场（pm-EMF） 30分钟后，进行正电子发射断层扫描（PET）扫描。在实验2中，电磁场暴露后，用多导睡眠仪记录夜间睡眠。脉冲调制EMF暴露增加了暴露同侧前额叶皮层背外侧相对rCBF。此外，pm-EMF暴露增强了睡眠开始前α频率范围和第二阶段睡眠期间纺锤波频率范围的脑电图功率。在没有脉冲调制的情况下暴露于电磁场并没有增强清醒或睡眠时脑电图的功率。我们之前观察到电磁场对睡眠脑电图的影响（A. A. Borbely， R. Huber， T. Graf， B. Fuchs， E. Gallmann和P. Achermann）。>。列托人。植物学报，1999,27:207210；R. Huber， T. Graf， K. A. Cote， L. Wittmann， E. Gallmann， D. Matter， J. Schuderer， N. Kuster， A. A. Borbely和P. Achermann。神经报告，2000,11:3321 3325)，但这些影响的基础是未知的。目前的研究结果首次表明：(1)pm-EMF改变清醒时的rCBF；(2)脉冲调制EMF是诱发清醒和睡眠时脑电图变化的必要条件。脉冲调制EMF暴露可能为实验、诊断和治疗目的提供一种新的、非侵入性的改变脑功能的方法。
Usage of mobile phones is rapidly increasing, but there is limited data on the possible effects of electromagnetic field (EMF) exposure on brain physiology. We investigated the effect of EMF vs. sham control exposure on waking regional cerebral blood flow (rCBF) and on waking and sleep electroencephalogram ( EEG) in humans. In Experiment 1, positron emission tomography (PET) scans were taken after unilateral head exposure to 30-min pulse-modulated 900 MHz electromagnetic eld (pm-EMF). In Experiment 2, night-time sleep was polysomnographically recorded after EMF exposure. Pulse-modulated EMF exposure increased relative rCBF in the dorsolateral prefrontal cortex ipsilateral to exposure. Also, pm-EMF exposure enhanced EEG power in the alpha frequency range prior to sleep onset and in the spindle frequency range during stage 2 sleep. Exposure to EMF without pulse modulation did not enhance power in the waking or sleep EEG. We previously observed EMF effects on the sleep EEG ( A. A. Borbely, R. Huber, T. Graf, B. Fuchs, E. Gallmann and P. Achermann. Neurosci. Lett., 1999, 275: 207 210; R. Huber, T. Graf, K. A. Cote, L. Wittmann, E. Gallmann, D. Matter, J. Schuderer, N. Kuster, A. A. Borbely, and P. Achermann. Neuroreport, 2000, 11: 3321 3325), but the basis for these effects was unknown. The present results show for the first time that (1) pm-EMF alters waking rCBF and (2) pulse modulation of EMF is necessary to induce waking and sleep EEG changes. Pulse-modulated EMF exposure may provide a new, non-invasive method for modifying brain function for experimental, diagnostic and therapeutic purposes.