Modulation of excitability in human primary somatosensory and motor cortex by paired associative stimulation targeting the primary somatosensory cortex
Modulation of excitability in human primary somatosensory and motor cortex by paired associative stimulation targeting the primary somatosensory cortex
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DOI：
10.1111/j.1460-9568.2011.07849.x
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发表时间：
2011-10-01
影响因子：
3.4
通讯作者：
Ziemann, Ulf
中科院分区：
文献类型：
--
作者：
Krivanekova, Lucia;Lu, Ming-Kuei;Ziemann, Ulf
初级躯体感觉皮层（S1）向初级运动皮层（M1）的输入对于高水平运动表现、运动技能学习和脑损伤后运动恢复至关重要。本研究考察了配对联合经颅刺激（S1- pas）对M1兴奋性的影响。鉴于S1在感觉运动整合中的重要作用，我们假设S1兴奋性的变化与M1兴奋性的变化直接平行。我们将两种已建立的方案（S1- pasltp和S1- pasltd）应用于左S1以诱导长时程增强（LTP）样或长时程抑制（LTD）样可塑性。采用正中神经体感诱发电位早期皮质成分（N20P25）评估S1兴奋性。M1兴奋性通过运动诱发电位振幅和短间隔皮质内抑制来评估。比较S1-PASLTP方案与针对左侧M1 （M1-PASLTP）的PASLTP方案的效果。由于个体间的差异，S1- pasltp和S1- pasltd在组水平上没有导致S1或M1兴奋性的显著改变。个体S1- pas诱导的S1和M1兴奋性变化无相关性。此外，S1- pasltp引起的S1和M1兴奋性的个体变化与M1- pasltp引起的M1兴奋性变化不相关。这表明S1- pas的影响在个体之间是可变的，并且在给定个体内，与S1- pas或M1- pas诱导的影响无关。潜在地，这扩大了治疗性PAS应用的机会，因为M1-PAS无反应者可能对S1-PAS有很好的反应。
Input from primary somatosensory cortex (S1) to primary motor cortex (M1) is important for high-level motor performance, motor skill learning and motor recovery after brain lesion. This study tested the effects of manipulating S1 excitability with paired associative transcranial stimulation (S1-PAS) on M1 excitability. Given the important role of S1 in sensorimotor integration, we hypothesized that changes in S1 excitability would be directly paralleled by changes in M1 excitability. We applied two established protocols (S1-PASLTP and S1-PASLTD) to the left S1 to induce long-term potentiation (LTP)-like or long-term depression (LTD)-like plasticity. S1 excitability was assessed by the early cortical components (N20P25) of the median nerve somatosensory-evoked potential. M1 excitability was assessed by motor-evoked potential amplitude and short-interval intracortical inhibition. Effects of S1-PASLTP were compared with those of a PASLTP protocol targeting the left M1 (M1-PASLTP). S1-PASLTP and S1-PASLTD did not result in significant modifications of S1 or M1 excitability at the group level due to substantial interindividual variability. The individual S1-PAS-induced changes in S1 and M1 excitability showed no correlation. Furthermore, the individual changes in S1 and M1 excitability induced by S1-PASLTP did not correlate with changes in M1 excitability induced by M1-PASLTP. This demonstrates that the effects of S1-PAS in S1 are variable across individuals and, within a given individual, unrelated to those induced by S1-PAS or M1-PAS in M1. Potentially, this extends the opportunities of therapeutic PAS applications because M1-PAS non-responders may well respond to S1-PAS.