Supramolecular Hunter Stationed on Red Blood Cells for Detoxification Based on Specific Molecular Recognition
Supramolecular Hunter Stationed on Red Blood Cells for Detoxification Based on Specific Molecular Recognition
复制标题
基于特定分子识别的超分子猎人驻扎在红细胞上进行解毒
DOI：
10.1021/acsnano.0c01119
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发表时间：
2020-04-28
期刊：
影响因子：
17.1
通讯作者：
Sun, Tao
中科院分区：
文献类型：
--
作者：
Li, Chao;Xie, Zichen;Sun, Tao
血液净化对致命毒物的有效清除在中毒治疗中仍占主导地位。目前的策略主要依赖于吸收清除剂，这些清除剂通常对吸附物没有选择性，由于解毒过程的被动性和不准确性，这可能会导致某些有毒物种的临床结果不佳。为此，提出了一种积极、准确、个性化的戒毒策略。基于对目标毒物百草枯复杂的分子设计和深思熟虑的结构分析，研制了一种驻留在红细胞上的超分子猎人，用于连续追踪血液中的百草枯。在这种结构中，我们合成了一种两亲性的双亲分子Janus Dendrimer(DA)，其目的是在桥接能准确识别百草枯的解毒剂WP6的同时，容易地锚定在红细胞膜上。体外和体内结果表明，该系统通过客体交换反应，具有有效的毒物猎杀和中和伤害的能力。这一策略为设计能够通过超分子方法积极、准确并持续寻找毒物的清道夫提供了不同的见解。
Efficient removal of deadly toxicants by blood purification remains predominant in poisoning treatment. Current strategies mainly rely on absorptive scavengers that normally have no selectivity to the adsorbates, which could result poor clinical outcomes to certain toxic species due to the passivity and inaccuracy of the detoxification procedure. Herein, a positive, accurate, and customized detoxification strategy was proposed. Based on the sophisticated molecule design and thoughtful structure analysis of the aimed toxicant paraquat, a supramolecular hunter stationed on red blood cells (RBC) is developed to continuously track paraquat in the blood. In this construct, a Janus dendrimer amphiphile (DA) molecule was synthesized with the aim of facilely anchoring onto RBC membranes while bridging to load the antidote WP6 that could precisely recognize paraquat. In vitro and in vivo results demonstrate the effective toxicant-hunting and harm-neutralizing capability of the system through a guest-exchange reaction. This strategy provides a different insight in designing scavengers that can actively, precisely, and continuously hunt toxicants through a supramolecular approach.