A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS
A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS
复制标题
DOI：
10.1073/pnas.40.4.228
复制
发表时间：
1954-01-01
影响因子：
11.1
通讯作者：
SHAW, E
中科院分区：
文献类型：
--
作者：
WOOLLEY, DW;SHAW, E
在实验室老鼠身上的实验表明，几种合成化合物和麦角生物碱（在结构上与麦角样物质5-羟色胺有关）可以拮抗5-羟色胺对动脉壁的作用。由于麦角生物碱的衍生物麦角酸二乙基酰胺在平滑肌上充当5-羟色胺的抗代谢物，并能在人身上产生类似于精神分裂症的精神障碍，这些障碍可能是由于干扰了5-羟色胺在大脑中的作用。育亨宾和骆驼蓬生物碱（其结构类似于5-羟色胺）以及合成化合物麦德曼和肼基酞嗪也有类似的作用。精神分裂症的自然发生可能是由于中枢神经系统中缺乏5-羟色胺，在这种情况下，建议将5-羟色胺或其长效衍生物给予人类精神病人。
Experiments on laboratory mice showed that several synthetic compounds and the ergot alkaloids, which are related structurally to the hormone-like substance, serotonin, antagonize the action of serotonin on artery walls. Since a derivative of the ergot alkaloids, lysergic acid diethylamide, acts as an antimetabolite of serotonin on smooth muscles and can produce in man mental disturbances similar to schizophrenia, these disturbances may be due to an interference with the action of serotonin in the brain. Similar effects were found for yohimbine and the harmala alkaloids which resemble serotonin structurally, and also for the synthetic compounds medmain and hydrazinophthalazine. It is possible that the natural occurrence of schizophrenia is due to a deficiency of serotonin in the central nervous system, in which case it is suggested that serotonin or a long-acting derivative of it be given to human mental patients.