The effect of SARS-COV-2 variant on non-respiratory features and mortality among vaccinated and non-fully vaccinated patients.
The effect of SARS-COV-2 variant on non-respiratory features and mortality among vaccinated and non-fully vaccinated patients.
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DOI：
10.1016/j.vaccine.2024.02.036
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发表时间：
2024-03
期刊：
影响因子：
5.5
通讯作者：
Shannon A. Cotton;Ajan Subramanian;Thomas D. Hughes;Yong Huang;C. Sierra;A. Pearce;Atul Malhotra;Amir-Mohammad Rahmani;C. A. Downs;Melissa D. Pinto
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文献类型：
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作者：
Shannon A. Cotton;Ajan Subramanian;Thomas D. Hughes;Yong Huang;C. Sierra;A. Pearce;Atul Malhotra;Amir-Mohammad Rahmani;C. A. Downs;Melissa D. Pinto
目的使用加州大学数据库确定SARS-CoV-2变异体对接种疫苗和未完全接种疫苗患者COVID-19非呼吸系统特征的影响。（n = 63，454），使用UCCORDS数据库比较非呼吸系统特征、疫苗接种状态，和死亡率之间的差异。卡方检验被用来研究使用列联matrix.ResultsFever的分类变量之间的关系是最常见的功能在所有的变量。在Delta和Omicron波期间，未完全接种疫苗的发热显著更高（p = 0.001; p = 0.001）。在Omicron期间未完全接种疫苗的心脏特征在统计学上更高;心动过速仅是Delta和Omicron期间未完全接种疫苗的特征;糖尿病和GI反流是所有变体的特征，无论疫苗状态如何。在Delta和Omicron变体中未完全接种疫苗的人群中，死亡几率显著增加（Delta OR：1.64，p = 0.052; Omicron OR：1.96，p < 0.01）。接种疫苗与非呼吸道特征的频率下降相关。结论在所有变异中，未完全接种疫苗的人患COVID-19非呼吸道特征的风险在统计学上更高。死亡风险和与疫苗接种状况的相关性各不相同。
ObjectiveTo determine the effect of SARS-CoV-2 variants on non-respiratory features of COVID-19 in vaccinated and not fully vaccinated patients using a University of California database.MethodsA longitudinal retrospective review of medical records (n = 63,454) from 1/1/2020–4/26/2022 using the UCCORDS database was performed to compare non-respiratory features, vaccination status, and mortality between variants. Chi-square tests were used to study the relationship between categorical variables using a contingency matrix.ResultsFever was the most common feature across all variants. Fever was significantly higher in not fully vaccinated during the Delta and Omicron waves (p = 0.001; p = 0.001). Cardiac features were statistically higher in not fully vaccinated during Omicron; tachycardia was only a feature of not fully vaccinated during Delta and Omicron; diabetes and GI reflux were features of all variants regardless of vaccine status. Odds of death were significantly increased among those not fully vaccinated in the Delta and Omicron variants (Delta OR: 1.64,p= 0.052; Omicron OR: 1.96,p< 0.01). Vaccination was associated with a decrease in the frequency of non-respiratory features.ConclusionsRisk of non-respiratory features of COVID-19 is statistically higher in those not fully vaccinated across all variants. Risk of death and correlation with vaccination status varied.