Adherence to adjuvant endocrine therapy for breast cancer: a qualitative exploration of attribution of symptoms among post-menopausal women.
Adherence to adjuvant endocrine therapy for breast cancer: a qualitative exploration of attribution of symptoms among post-menopausal women.
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坚持乳腺癌辅助内分泌治疗：绝经后妇女症状归因的定性探索。
DOI：
10.1007/s00520-024-08463-w
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Flynn,KathrynE
中科院分区：
文献类型：
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作者：
Lee,AmyY;Lyons,AnnaT;Makris,Vaia;Kamaraju,Sailaja;Stolley,MelindaR;Neuner,JoanM;Flynn,KathrynE
目的口服辅助内分泌治疗（AET）是激素受体阳性乳腺癌降低复发率和死亡率的有效治疗方法，但依从性差。本研究探讨了绝经后妇女的经验与AET，特别注重坚持AET以及痛苦和症状经历之前和AET treatment.MethodsParticipants招募从医院登记处，分层的坚持/中止AET。电话访谈遵循半结构化访谈指南，并进行了录音和逐字记录。成绩单进行了系统的编码，使用团队为基础的编码，与分析的主题，采用扎根理论approach.ResultsThirty-three参与者进行了采访，年龄范围从57至86岁。参与者包括10名中止治疗的患者和23名完成AET课程或在访谈时坚持AET的患者。在整个AET治疗过程中，依从和中止治疗的患者均报告了症状，并且均将症状归因于AET以外的因素（例如，老年和先前存在的合并症）。然而，中止治疗的患者更可能将症状归因于AET，并描述难以控制其症状，其中一些患者直接将症状作为中止AET治疗的原因。相反，遵守患者更有可能描述的必要性，采取AET，尽管symptoms.ConclusionsAET的坚持与信念AET，症状归因，和症状管理。AET期间的常规症状监测以及解决症状和患者对其症状的理解可能会促进AET的依从性。
PurposeOral adjuvant endocrine therapy (AET) is an effective treatment for hormone receptor positive breast cancer to decrease recurrence and mortality, but adherence is poor. This study explored post-menopausal women’s experiences with AET, with a particular focus on adherence to AET as well as distress and symptoms experienced prior to and during AET treatment.MethodsParticipants were recruited from a hospital registry, stratified by adherence to/discontinuation of AET. Telephone interviews followed a semi-structured interview guide and were recorded and transcribed verbatim. Transcripts were systematically coded using team-based coding, with analysis of themes using a grounded theory approach.ResultsThirty-three participants were interviewed; ages ranged from 57 to 86 years. Participants included 10 discontinued patients and 23 patients who completed their AET course or were adherent to AET at the time of interviewing. Both adherent and discontinued patients reported symptoms throughout their AET treatment course, and both attributed symptoms to factors other than AET (e.g., older age and pre-existing comorbidities). However, discontinued patients were more likely to attribute symptoms to AET and to describe difficulty managing their symptoms, with some directly citing symptoms as the reason for discontinuing AET therapy. Conversely, adherent patients were more likely to describe the necessity of taking AET, despite symptoms.ConclusionsAET adherence was associated with beliefs about AET, symptom attribution, and symptom management. Routine symptom monitoring during AET and addressing both symptoms and patients’ understanding of their symptoms may promote adherence to AET.