AGE-RELATED LOSS OF AUDITORY-SENSITIVITY IN 2 MOUSE GENOTYPES
AGE-RELATED LOSS OF AUDITORY-SENSITIVITY IN 2 MOUSE GENOTYPES
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DOI：
10.3109/00016489109138418
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发表时间：
1991-01-01
影响因子：
1.4
通讯作者：
BORG, E
中科院分区：
文献类型：
--
作者：
LI, HS;BORG, E
频率特异性听觉脑干反应 (ABR)（频率范围 2-31.5 kHz）用于描述 CBA/ca（至 30 个月）和 C57BL/6J（至 16 个月）小鼠基因型的频率敏感性随年龄的变化。 这两种菌株表现出与人类相似的与年龄相关的损失，主要是高频敏感性下降。 CBA 小鼠对高频率的敏感性缓慢但逐渐下降，随后是低频，直到 18 个月大，此后对所有频率的敏感性迅速恶化。 C57 小鼠的听觉敏感性以不稳定而非渐进的方式出现早熟。 通过对同一个体的重复测试发现，C57小鼠的退行性过程更为急剧，分三个阶段，且个体变异性比CBA小鼠更大。 这表明这两种小鼠基因型可用于表达人类老年性聋的不同方面的个体变异性以及渐进或交错进展的模式。
Frequency-specific auditory brainstem responses (ABR) (frequency range 2-31.5 kHz) were used to describe age-dependent alterations in frequency sensitivity in CBA/ca (to 30 months) and C57BL/6J (to 16 months) mouse genotypes. The two strains displayed an age-related loss similar to that of humans, with a primary decline in high-frequency sensitivity. CBA mice showed a slow, yet gradual decrease in sensitivity to high- followed by low-frequency until 18 months of age and a rapid deterioration at all frequencies thereafter. C57 mice demonstrated precocious aging in auditory sensitivity in an unsteady rather than gradual manner. By testing the same individuals on repeated occasions it was shown that, for C57 mice, the degenerative process was more precipitous with three phases, and that the individual variability was larger than that of CBA mice. It is suggested that the two mouse genotypes can be used to express the different aspects of human presbycusis in individual variability and modes of gradual or staggered progression.