The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis.
The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis.
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DOI：
10.2217/clp.11.8
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发表时间：
2011-04
影响因子：
--
通讯作者：
Hogan EL
中科院分区：
文献类型：
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作者：
Podbielska M;Levery SB;Hogan EL
已表征了含有3-O-乙酰基-鞘氨醇半乳糖神经酰胺（3-SAG）的中性鞘糖脂家族。本文报道了七种新的半乳糖神经酰胺（GalCer）衍生物，经薄层色谱保留因子分析，命名为快速迁移糖苷（FMCs）。该系列中最简单的化合物- FMC-1和FMC-2 -已被表征为分别含有非羟基和羟基脂肪酰基的3-SAG。接下来的两个- FMC-3和FMC-4 -添加6-O-乙酰基-半乳糖，并且最复杂的鞘糖脂FMC-5、-6和-7是2，3，4，6-四-O-乙酰基-3-SAG。这些疏水性髓鞘脂质生物标志物在髓鞘形成期间与GalCer共同出现，并且在脱髓鞘或脱髓鞘疾病中与GalCer一起沿着消失。髓鞘脂质抗原，包括FMCs，是髓鞘生物学的关键，为治疗包括多发性硬化症在内的自身免疫性疾病开辟了新的和新颖的免疫调节工具的可能性。
A family of neutral glycosphingolipids containing a 3-O-acetyl-sphingosine galactosylceramide (3-SAG) has been characterized. Seven new derivatives of galactosylceramide (GalCer), designated as fast-migrating cerebrosides (FMCs) by TLC retention factor, have been identified. The simplest compounds – FMC-1 and FMC-2 – of this series have been characterized as the 3-SAG containing nonhydroxy and hydroxy fatty acyl, respectively. The next two – FMC-3 and FMC-4 – add 6-O-acetyl-galactose and the most complex glycosphingolipids, FMC-5, -6 and -7, are 2,3,4,6-tetra-O-acetyl-3-SAG. These hydrophobic myelin lipid biomarkers coappear with GalCer during myelinogenesis and disappear along with GalCer in de- or dys-myelinating disorders. Myelin lipid antigens, including FMCs, are keys to myelin biology, opening the possibility of new and novel immune modulatory tools for treatment of autoimmune diseases including multiple sclerosis.